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MAGAT 凝胶剂量计的配方优化和可重复使用性研究。

Study of the formulation optimization and reusability of a MAGAT gel dosimeter.

机构信息

Physics Department, Faculty of Philosophy, Sciences and Letters at Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, 14040-901, Monte Alegre, Ribeirão Preto, SP, Brazil.

Radiotherapy Service, Clinics Hospital of University of São Paulo Medical School at Ribeirão Preto, Av. Bandeirantes 3900, 14040-900, Monte Alegre, Ribeirão Preto, SP, Brazil.

出版信息

Phys Med. 2019 Jul;63:105-111. doi: 10.1016/j.ejmp.2019.05.018. Epub 2019 Jun 12.

Abstract

PURPOSE

This study aims to optimize the formulation of a methacrylic acid gelatine and tetrakis (hydroxymethyl) phosphonium chloride (MAGAT) gel dosimeter to achieve acceptable dosimetric characteristics and the lowest final costs. This study also evaluates the reusability of the dosimeter.

METHODS

The MAGAT gel dosimeter formulation was optimized. Tetrakis (hydroxymethyl) phosphonium chloride (THPC) concentrations (2, 5, 8, 10, 20, and 65 mM), methacrylic acid (MA) concentrations (2.0, 2.5, 3.0, 3.5, and 4.0% w/w) and gelatin concentrations (4.36, 6.45, 8.36, and 10.45% w/w) were evaluated to provide an adequate dosimetric response. The final dosimeter formulation linearity and dose rate dependence were evaluated. The reutilization methodology of the optimized gel formulation, but containing 2 mM of THPC, which was previously irradiated with a dose of 2 Gy, is also presented.

RESULTS

The optimized mass concentration of the dosimeter consists of 88.60% deionized water, 8.36% gelatin, 3.00% of MA and 0.04% THPC (5 mM). It presents a linear response for doses up to 10 Gy with a 1.16 Gy s sensitivity. A maximum sensitivity variation of less than 4.0% was found when varying the dose rate of the radiation beams from 300 to 500 cGy/min. It was possible to reuse the dosimeter, however the sensitivity decreased by 15% from the first to the second irradiation.

CONCLUSIONS

A low-cost MAGAT gel dosimeter with optimized formulation that responds to radiation in a dose range of 0 to 10 Gy with small dose-rate dependence is presented. The MAGAT gel can be reused after a 2 Gy irradiation.

摘要

目的

本研究旨在优化甲基丙烯酸明胶和四羟甲基氯化磷(MAGAT)凝胶剂量计的配方,以达到可接受的剂量特性和最低的最终成本。本研究还评估了剂量计的可重复使用性。

方法

优化了 MAGAT 凝胶剂量计配方。评估了四羟甲基氯化磷(THPC)浓度(2、5、8、10、20 和 65 mM)、甲基丙烯酸(MA)浓度(2.0、2.5、3.0、3.5 和 4.0%w/w)和明胶浓度(4.36、6.45、8.36 和 10.45%w/w),以提供足够的剂量响应。评估了最终剂量计配方的线性度和剂量率依赖性。还介绍了先前用 2 Gy 剂量照射后含有 2 mM THPC 的优化凝胶配方的再利用方法。

结果

优化的剂量计质量浓度由 88.60%去离子水、8.36%明胶、3.00%MA 和 0.04%THPC(5 mM)组成。它在 0 至 10 Gy 的剂量范围内呈线性响应,灵敏度为 1.16 Gy s。当辐射束的剂量率从 300 至 500 cGy/min 变化时,发现最大灵敏度变化小于 4.0%。剂量计可以重复使用,但是从第一次照射到第二次照射,灵敏度下降了 15%。

结论

本研究提出了一种低成本的 MAGAT 凝胶剂量计,其配方经过优化,可在 0 至 10 Gy 的辐射剂量范围内响应,剂量率依赖性较小。MAGAT 凝胶在接受 2 Gy 照射后可重复使用。

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