阿魏酸：一种有前景的治疗性植物化学物质及近期专利进展
Ferulic Acid: A Promising Therapeutic Phytochemical and Recent Patents Advances.
作者信息
Chaudhary Ashun, Jaswal Vivek S, Choudhary Sonika, Sharma Ajay, Beniwal Vikas, Tuli Hardeep S, Sharma Sanjeev
机构信息
Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala-133207, Haryana, India.
Government Senior School Kanol, Shahpur, Kangra, Himachal Pradesh Board of School Education - 176215, Himachal Pradesh, India.
出版信息
Recent Pat Inflamm Allergy Drug Discov. 2019;13(2):115-123. doi: 10.2174/1872213X13666190621125048.
BACKGROUND
Among the various phenolics metabolites, ferulic acid is considered as the promising mitigating, restorative and antioxidant agent. Ferulic acid is one of the most commonly found natural products in vegetables, for example, tomatoes, sweet corn, and in rice grain. Phytochemicals are utilized in the treatment of human ailments and these are derived from the dietary compounds.
OBJECTIVE
The present review widely argued the calming restorative capability of ferulic acid alongside the scientific evidences and its proposed mechanism for activity. Furthermore, we provided the main practical points for the use of ferulic acid in oxidative damages during various diseases. Additionally, the relevant patents on ferulic acid with various therapeutic potential has been discussed.
METHODS
The approach consisted of searching several resources, including theses, technical reports, web-based scientific databases such as publications on PubMed, ScienceDirect, Springer, PROTA, Google Scholar, and other allied databases. Thus, recent patent regarding the role of ferulic acid therapeutic potenitial has been discussed.
RESULTS
One hundred and twenty references have been cited in the present review article. The cited references were found to be suitable and described the therapeutic application of ferulic acid thoroughly.
CONCLUSION
Ferulic acids are known to contrarily down-manage an assortment of extracellular and intrcelullular molecular targets related to infection movement. Various patents on ferulic acid based moieties have been accounted for from 2018. The ferulic acids have a wide scope of impacts against different infections like malignant growth, diabetes, cardiovascular and neurodegenerative diseases. The current review deals with the antioxidant property of ferulic acid and the recent patent describes the role of ferulic acid against human diseases.
背景
在各种酚类代谢产物中，阿魏酸被认为是一种有前景的缓解、修复和抗氧化剂。阿魏酸是蔬菜中最常见的天然产物之一，例如番茄、甜玉米以及稻谷中。植物化学物质被用于治疗人类疾病，这些物质来源于饮食化合物。
目的
本综述广泛讨论了阿魏酸的舒缓修复能力及其科学证据和推测的活性机制。此外，我们还提供了阿魏酸在各种疾病氧化损伤中应用的主要实践要点。此外，还讨论了具有各种治疗潜力的阿魏酸相关专利。
方法
该方法包括搜索多种资源，包括论文、技术报告、基于网络的科学数据库，如PubMed、ScienceDirect、Springer、PROTA、谷歌学术等出版物以及其他相关数据库。因此，讨论了近期关于阿魏酸治疗潜力作用的专利。
结果
本综述文章引用了120篇参考文献。发现所引用的参考文献合适，并全面描述了阿魏酸的治疗应用。
结论
已知阿魏酸能反向下调与感染活动相关的多种细胞外和细胞内分子靶点。自2018年以来，已有多项关于基于阿魏酸部分的专利。阿魏酸对多种疾病如癌症、糖尿病、心血管疾病和神经退行性疾病具有广泛的影响。本综述探讨了阿魏酸的抗氧化特性，近期专利描述了阿魏酸对人类疾病的作用。
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