自我报告的长期抗逆转录病毒依从性：南非姆普马兰加省感染 HIV 的孕妇的纵向研究。
Self-Reported Long-Term Antiretroviral Adherence: A Longitudinal Study Among HIV Infected Pregnant Women in Mpumalanga, South Africa.
机构信息
Social Aspects of Public Health, Human Sciences Research Council, Private Bag X41, Pretoria, 0001, South Africa.
Department of Work & Social Psychology, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
出版信息
AIDS Behav. 2019 Sep;23(9):2576-2587. doi: 10.1007/s10461-019-02563-z.
We evaluate the impact of a multi-session cognitive behavioral prevention of mother to child transmission (PMTCT) intervention on antiretroviral therapy (ART) adherence. A total of 683 women were enrolled into a randomized control trial conducted at twelve community health centres (CHCs) in Mpumalanga Province. Participants were randomized to Standard Care or Enhanced PMTCT Intervention (EI). EI received three group and three individual intervention sessions. EI impact was ascertained on ART adherence (baseline vs 12 months post-partum). Women in the intervention groups were less likely to remain stable with regards to ART adherence over time compared to the control groups. In predicting if women become adherent over time, the intervention condition had no impact. However, the intervention condition was significantly positively associated with change to non-adherence. The enhanced cognitive-behavioral PMTCT intervention did not show any improvement in relation to maternal ART adherence relative to standard PMTCT care.Trial registration Clinicaltrials.gov: number NCT02085356.
我们评估了多次认知行为预防母婴传播（PMTCT）干预对接受抗逆转录病毒治疗（ART）的依从性的影响。共有 683 名妇女参加了在姆普马兰加省 12 个社区卫生中心（CHC）进行的一项随机对照试验。参与者被随机分配到标准护理或增强型 PMTCT 干预（EI）组。EI 接受了三次小组和三次个体干预。EI 对 ART 依从性（基线与产后 12 个月）的影响进行了评估。与对照组相比，干预组的妇女在 ART 依从性方面不太可能随着时间的推移保持稳定。在预测妇女是否会随着时间的推移而保持依从性时，干预条件没有影响。然而，干预条件与向不依从性的转变呈显著正相关。与标准 PMTCT 护理相比，增强型认知行为 PMTCT 干预并未显示在孕产妇 ART 依从性方面有任何改善。试验注册Clinicaltrials.gov：编号 NCT02085356。
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