哺乳期骨生理学之谜：骨细胞伪装成破骨细胞和成骨细胞。
The puzzle of lactational bone physiology: osteocytes masquerade as osteoclasts and osteoblasts.
出版信息
J Clin Invest. 2019 Jun 24;129(8):3041-3044. doi: 10.1172/JCI130640.
Abstract
Lactation is a unique period in which the maternal skeleton acts as a storehouse to provide substantial calcium to milk. Women who exclusively breastfeed lose an average of 210 mg of calcium per day, which doubles or triples with twins and triplets. Data from rodent and clinical studies are consistent with skeletal calcium being released to provide much of the calcium needed for milk production. This is programmed to occur independently of dietary calcium intake or intestinal calcium absorption, which remains at the prepregnant rate in breastfeeding women. After weaning, the skeleton is restored to its prior mineralization and strength, but the factors that regulate this remain to be elucidated.
摘要
哺乳期是母体骨骼作为钙库向乳汁大量提供钙的独特时期。纯母乳喂养的女性每天平均损失 210 毫克钙，双胎和三胎的损失量增加一倍或三倍。啮齿动物和临床研究的数据表明，骨骼钙被释放以提供大部分产奶所需的钙。这一过程独立于膳食钙摄入或肠道钙吸收而发生，哺乳期妇女的肠道钙吸收仍保持在怀孕前的水平。断奶后，骨骼恢复到先前的矿化和强度，但调节这一过程的因素仍有待阐明。
相似文献
1
The puzzle of lactational bone physiology: osteocytes masquerade as osteoclasts and osteoblasts.
J Clin Invest. 2019 Jun 24;129(8):3041-3044. doi: 10.1172/JCI130640.
2
The Skeleton Is a Storehouse of Mineral That Is Plundered During Lactation and (Fully?) Replenished Afterwards.
J Bone Miner Res. 2017 Apr;32(4):676-680. doi: 10.1002/jbmr.3090. Epub 2017 Feb 28.
3
The actions of parathyroid hormone on bone: relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone disease. Part I of IV parts: mechanisms of calcium transfer between blood and bone and their cellular basis: morphological and kinetic approaches to bone turnover.
Metabolism. 1976 Jul;25(7):809-44. doi: 10.1016/0026-0495(76)90151-7.
4
Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression.
J Clin Invest. 2019 May 21;129(8):3058-3071. doi: 10.1172/JCI122936.
5
[The effects of pregnancy and lactation on bone and mineral metabolism.].
Clin Calcium. 2019;29(1):35-38.
6
Rapid inactivation and apoptosis of osteoclasts in the maternal skeleton during the bone remodeling reversal at the end of lactation.
Anat Rec (Hoboken). 2007 Jan;290(1):65-73. doi: 10.1002/ar.20403.
7
Upregulation of calcitriol during pregnancy and skeletal recovery after lactation do not require parathyroid hormone.
J Bone Miner Res. 2013 Sep;28(9):1987-2000. doi: 10.1002/jbmr.1925.
8
Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery.
Physiol Rev. 2016 Apr;96(2):449-547. doi: 10.1152/physrev.00027.2015.
9
Prepregnant overweight and obesity diminish the prolactin response to suckling in the first week postpartum.
Pediatrics. 2004 May;113(5):e465-71. doi: 10.1542/peds.113.5.e465.
引用本文的文献
1
Connexin hemichannels drive lactation-induced osteocyte acidification and perilacunar-canalicular remodeling.
Cell Rep. 2024 Jul 23;43(7):114363. doi: 10.1016/j.celrep.2024.114363. Epub 2024 Jun 26.
2
Spatial control of perilacunar canalicular remodeling during lactation.
Sci Rep. 2024 Jun 25;14(1):14655. doi: 10.1038/s41598-024-63645-0.
3
Recent Insights into Pregnancy and Lactation-Associated Osteoporosis (PLO).
Int J Womens Health. 2023 Aug 2;15:1227-1238. doi: 10.2147/IJWH.S366254. eCollection 2023.
4
Peripartal treatment with low-dose sertraline accelerates mammary gland involution and has minimal effects on maternal and offspring bone.
Physiol Rep. 2022 Mar;10(5):e15204. doi: 10.14814/phy2.15204.
5
European Expert Consensus on Practical Management of Specific Aspects of Parathyroid Disorders in Adults and in Pregnancy: Recommendations of the ESE Educational Program of Parathyroid Disorders.
Eur J Endocrinol. 2022 Jan 13;186(2):R33-R63. doi: 10.1530/EJE-21-1044. Print 2022 Feb 1.
6
Severe Bone Microarchitecture Impairment in Women With Pregnancy and Lactation-Associated Osteoporosis.
J Endocr Soc. 2021 Feb 26;5(5):bvab031. doi: 10.1210/jendso/bvab031. eCollection 2021 May 1.
7
Elevated serotonin coordinates mammary metabolism in dairy cows.
Physiol Rep. 2021 Apr;9(7):e14798. doi: 10.14814/phy2.14798.
8
Hormonal regulation of biomineralization.
Nat Rev Endocrinol. 2021 May;17(5):261-275. doi: 10.1038/s41574-021-00477-2. Epub 2021 Mar 16.
本文引用的文献
1
Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression.
J Clin Invest. 2019 May 21;129(8):3058-3071. doi: 10.1172/JCI122936.
2
Parity and lactation are not associated with incident fragility fractures or radiographic vertebral fractures over 16 years of follow-up: Canadian Multicentre Osteoporosis Study (CaMos).
Arch Osteoporos. 2019 Apr 29;14(1):49. doi: 10.1007/s11657-019-0601-6.
3
Absence of Calcitriol Causes Increased Lactational Bone Loss and Lower Milk Calcium but Does Not Impair Post-lactation Bone Recovery in Cyp27b1 Null Mice.
J Bone Miner Res. 2018 Jan;33(1):16-26. doi: 10.1002/jbmr.3217. Epub 2017 Aug 2.
4
Associations of Parity, Breastfeeding, and Fractures in the Women's Health Observational Study.
Obstet Gynecol. 2017 Jul;130(1):171-180. doi: 10.1097/AOG.0000000000002096.
5
Irreversible Deterioration of Cortical and Trabecular Microstructure Associated With Breastfeeding.
J Bone Miner Res. 2017 Apr;32(4):681-687. doi: 10.1002/jbmr.3018. Epub 2016 Nov 30.
6
Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery.
Physiol Rev. 2016 Apr;96(2):449-547. doi: 10.1152/physrev.00027.2015.
7
OPG Treatment Prevents Bone Loss During Lactation But Does Not Affect Milk Production or Maternal Calcium Metabolism.
Endocrinology. 2015 Aug;156(8):2762-73. doi: 10.1210/en.2015-1232. Epub 2015 May 11.
8
Changes in cortical volumetric bone mineral density and thickness, and trabecular thickness in lactating women postpartum.
J Clin Endocrinol Metab. 2015 Feb;100(2):535-43. doi: 10.1210/jc.2014-2825. Epub 2014 Nov 11.
9
Upregulation of calcitriol during pregnancy and skeletal recovery after lactation do not require parathyroid hormone.
J Bone Miner Res. 2013 Sep;28(9):1987-2000. doi: 10.1002/jbmr.1925.
10
Lactating Ctcgrp nulls lose twice the normal bone mineral content due to fewer osteoblasts and more osteoclasts, whereas bone mass is fully restored after weaning in association with up-regulation of Wnt signaling and other novel genes.
Endocrinology. 2013 Apr;154(4):1400-13. doi: 10.1210/en.2012-1931. Epub 2013 Mar 5.
Zotero 插件