一项关于重度抑郁症中心率变异性的荟萃分析。

A meta-analysis of heart rate variability in major depression.

机构信息

Clinical Psychology and Psychotherapy, Philipps Universität, Marburg, Germany.

Clinical Psychology and Psychotherapy, Medical School Berlin, Berlin, Germany.

出版信息

Psychol Med. 2019 Sep;49(12):1948-1957. doi: 10.1017/S0033291719001351. Epub 2019 Jun 26.

DOI:10.1017/S0033291719001351

PMID:31239003

Abstract

BACKGROUND

Major depression (MD) is a risk factor for cardiovascular disease. Reduced heart rate variability (HRV) has been observed in MD. Given the predictive value of HRV for cardiovascular health, reduced HRV might be one physiological factor that mediates this association.

METHODS

The purpose of this study was to provide up-to-date random-effects meta-analyses of studies which compare resting-state measures of HRV between unmedicated adults with MD and controls. Database search considered English and German literature to July 2018.

RESULTS

A total of 21 studies including 2250 patients and 1982 controls were extracted. Significant differences between patients and controls were found for (i) frequency domains such as HF-HRV [Hedges' g = -0.318; 95% CI (-0.388 to -0.247)], LF-HRV (Hedges' g = -0.195; 95% CI (-0.332 to -0.059)], LF/HF-HRV (Hedges' g = 0.195; 95% CI (0.086-0.303)] and VLF-HRV (Hedges' g = -0.096; 95% CI (-0.179 to -0.013)), and for (ii) time-domains such as IBI (Hedges' g = -0.163; 95% CI (-0.304 to -0.022)], RMSSD (Hedges' g = -0.462; 95% CI (-0.612 to -0.312)] and SDNN (Hedges' g = -0.266; 95% CI (-0.431 to -0.100)].

CONCLUSIONS

Our findings demonstrate that all HRV-measures were lower in MD than in healthy controls and thus strengthens evidence for lower HRV as a potential cardiovascular risk factor in these patients.

摘要

背景

重度抑郁症（MD）是心血管疾病的一个风险因素。在 MD 中观察到心率变异性（HRV）降低。鉴于 HRV 对心血管健康的预测价值，HRV 降低可能是介导这种关联的一个生理因素。

方法

本研究的目的是提供最新的随机效应荟萃分析，比较未经治疗的 MD 成年患者与对照组之间静息状态下 HRV 的测量值。数据库检索考虑了截至 2018 年 7 月的英文和德文文献。

结果

共提取了 21 项研究，包括 2250 名患者和 1982 名对照。患者与对照组之间在（i）频域方面存在显著差异，如 HF-HRV[Hedges' g = -0.318；95%置信区间（-0.388 至 -0.247）]、LF-HRV（Hedges' g = -0.195；95%置信区间（-0.332 至 -0.059）]、LF/HF-HRV（Hedges' g = 0.195；95%置信区间（0.086 至 0.303）]和 VLF-HRV（Hedges' g = -0.096；95%置信区间（-0.179 至 -0.013）]，以及在（ii）时域方面，如 IBI（Hedges' g = -0.163；95%置信区间（-0.304 至 -0.022）]、RMSSD（Hedges' g = -0.462；95%置信区间（-0.612 至 -0.312）]和 SDNN（Hedges' g = -0.266；95%置信区间（-0.431 至 -0.100）]。