维生素 D 在 AGE/RAGE 相关心血管疾病中的治疗潜力。
Therapeutic potential of vitamin D in AGE/RAGE-related cardiovascular diseases.
机构信息
Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, 111 Xinglong Road, Section 3 Wenshan District, Taipei, 11696, Taiwan.
出版信息
Cell Mol Life Sci. 2019 Oct;76(20):4103-4115. doi: 10.1007/s00018-019-03204-3. Epub 2019 Jun 27.
Abstract
Cardiovascular diseases (CVDs) are among the leading threats to human health. The advanced glycation end product (AGE) and receptor for AGE (RAGE) signaling pathway regulates the pathogenesis of CVDs, through its effects on arterial stiffness, atherosclerosis, mitochondrial dysfunction, oxidative stress, calcium homeostasis, and cytoskeletal function. Targeting the AGE/RAGE pathway is a potential therapeutic strategy for ameliorating CVDs. Vitamin D has several beneficial effects on the cardiovascular system. Experimental findings have shown that vitamin D regulates AGE/RAGE signaling and its downstream effects. This article provides a comprehensive review of the mechanistic insights into AGE/RAGE involvement in CVDs and the modulation of the AGE/RAGE signaling pathways by vitamin D.
摘要
心血管疾病 (CVDs) 是对人类健康的主要威胁之一。晚期糖基化终产物 (AGE) 和 AGE 受体 (RAGE) 信号通路通过影响动脉僵硬、动脉粥样硬化、线粒体功能障碍、氧化应激、钙稳态和细胞骨架功能来调节 CVDs 的发病机制。靶向 AGE/RAGE 通路是改善 CVDs 的一种潜在治疗策略。维生素 D 对心血管系统有多种有益作用。实验结果表明，维生素 D 可调节 AGE/RAGE 信号及其下游效应。本文全面综述了 AGE/RAGE 参与 CVDs 的机制见解，以及维生素 D 对 AGE/RAGE 信号通路的调节。
相似文献
1
Therapeutic potential of vitamin D in AGE/RAGE-related cardiovascular diseases.
Cell Mol Life Sci. 2019 Oct;76(20):4103-4115. doi: 10.1007/s00018-019-03204-3. Epub 2019 Jun 27.
2
Molecular Pathways Involved in the Amelioration of Myocardial Injury in Diabetic Rats by Kaempferol.
Int J Mol Sci. 2017 May 15;18(5):1001. doi: 10.3390/ijms18051001.
3
Calcitriol modulates receptor for advanced glycation end products (RAGE) in diabetic hearts.
Int J Cardiol. 2014 May 1;173(2):236-41. doi: 10.1016/j.ijcard.2014.02.041. Epub 2014 Feb 28.
4
Advanced glycation end products receptor RAGE controls myocardial dysfunction and oxidative stress in high-fat fed mice by sustaining mitochondrial dynamics and autophagy-lysosome pathway.
Free Radic Biol Med. 2017 Nov;112:397-410. doi: 10.1016/j.freeradbiomed.2017.08.012. Epub 2017 Aug 19.
5
Soluble receptor for advanced glycation end-products promotes angiogenesis through activation of STAT3 in myocardial ischemia/reperfusion injury.
Apoptosis. 2020 Jun;25(5-6):341-353. doi: 10.1007/s10495-020-01602-8.
6
Advanced glycation end products and their receptor in age-related, non-communicable chronic inflammatory diseases; Overview of clinical evidence and potential contributions to disease.
Int J Biochem Cell Biol. 2016 Dec;81(Pt B):403-418. doi: 10.1016/j.biocel.2016.06.016. Epub 2016 Jun 29.
7
Integral role of receptor for advanced glycation end products (RAGE) in nondiabetic atherosclerosis.
Fukushima J Med Sci. 2019;65(3):109-121. doi: 10.5387/fms.2019-12.
8
Advanced glycation end products accelerate rat vascular calcification through RAGE/oxidative stress.
BMC Cardiovasc Disord. 2013 Mar 5;13:13. doi: 10.1186/1471-2261-13-13.
9
RAGE and its ligands: from pathogenesis to therapeutics.
Crit Rev Biochem Mol Biol. 2020 Dec;55(6):555-575. doi: 10.1080/10409238.2020.1819194. Epub 2020 Sep 16.
10
Agents that block advanced glycation end product (AGE)-RAGE (receptor for AGEs)-oxidative stress system: a novel therapeutic strategy for diabetic vascular complications.
Expert Opin Investig Drugs. 2008 Jul;17(7):983-96. doi: 10.1517/13543784.17.7.983.
引用本文的文献
1
Vitamin D ameliorates prediabetic cardiac injure via modulation of the ErbB4/ferroptosis signaling axis.
Front Immunol. 2025 Jul 17;16:1626295. doi: 10.3389/fimmu.2025.1626295. eCollection 2025.
2
The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial.
Adv Biomed Res. 2024 Sep 23;13:79. doi: 10.4103/abr.abr_380_23. eCollection 2024.
3
THBru attenuates diabetic cardiomyopathy by inhibiting RAGE-dependent inflammation.
Acta Pharmacol Sin. 2024 Oct;45(10):2107-2118. doi: 10.1038/s41401-024-01307-7. Epub 2024 Jun 11.
4
Molecular mechanisms of metabolic dysregulation in diabetic cardiomyopathy.
Front Cardiovasc Med. 2024 Mar 25;11:1375400. doi: 10.3389/fcvm.2024.1375400. eCollection 2024.
5
Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth.
Nutrients. 2024 Mar 21;16(6):906. doi: 10.3390/nu16060906.
6
Molecular targets and mechanisms of on diabetic cardiomyopathy based on network pharmacology.
World J Diabetes. 2023 Nov 15;14(11):1659-1671. doi: 10.4239/wjd.v14.i11.1659.
7
Sex Differences in Arteriovenous Fistula Failure: Insights from Bioinformatics Analysis.
J Cardiovasc Dev Dis. 2022 Dec 22;10(1):3. doi: 10.3390/jcdd10010003.
8
Single-cell transcriptomic, transcriptomic, and metabolomic characterization of human atherosclerosis.
Ann Transl Med. 2022 Nov;10(22):1215. doi: 10.21037/atm-22-4852.
9
Exploration of the Mechanism of Tripterygium Wilfordii in the Treatment of Myocardial Fibrosis Based on Network Pharmacology and Molecular Docking.
Curr Comput Aided Drug Des. 2023;19(1):68-79. doi: 10.2174/1573409919666221028120329.
10
Integrated Bioinformatics Analysis and Verification of Gene Targets for Myocardial Ischemia-Reperfusion Injury.
Evid Based Complement Alternat Med. 2022 Apr 15;2022:2056630. doi: 10.1155/2022/2056630. eCollection 2022.
本文引用的文献
1
Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease.
N Engl J Med. 2019 Jan 3;380(1):33-44. doi: 10.1056/NEJMoa1809944. Epub 2018 Nov 10.
2
Vitamin D attenuates human gingival fibroblast inflammatory cytokine production following advanced glycation end product interaction with receptors for AGE.
J Periodontal Res. 2019 Apr;54(2):154-163. doi: 10.1111/jre.12613. Epub 2018 Oct 8.
3
Serum 25-hydroxyvitamin D is associated with advanced glycation end products (AGEs) measured as skin autofluorescence: The Rotterdam Study.
Eur J Epidemiol. 2019 Jan;34(1):67-77. doi: 10.1007/s10654-018-0444-2. Epub 2018 Sep 25.
4
Vitamin D attenuates the effect of advanced glycation end products on anti-Mullerian hormone signaling.
Mol Cell Endocrinol. 2019 Jan 5;479:87-92. doi: 10.1016/j.mce.2018.09.004. Epub 2018 Sep 22.
5
Vitamin D and cardiovascular disease.
Maturitas. 2018 Sep;115:1-22. doi: 10.1016/j.maturitas.2018.05.010. Epub 2018 Jun 5.
6
Advanced glycation end products alter steroidogenic gene expression by granulosa cells: an effect partially reversible by vitamin D.
Mol Hum Reprod. 2018 Jun 1;24(6):318-326. doi: 10.1093/molehr/gay014.
7
Effect of Vitamin D Receptor Activation on the AGE/RAGE System and Myeloperoxidase in Chronic Kidney Disease Patients.
Oxid Med Cell Longev. 2017;2017:2801324. doi: 10.1155/2017/2801324. Epub 2017 Dec 6.
8
Advanced Glycation End Products, Oxidation Products, and Incident Cardiovascular Events in Patients With Type 2 Diabetes.
Diabetes Care. 2018 Mar;41(3):570-576. doi: 10.2337/dc17-1740. Epub 2017 Dec 5.
9
Serum levels of 25-hydroxyvitamin D predicts infarct volume and mortality in ischemic stroke patients.
J Neuroimmunol. 2017 Dec 15;313:41-45. doi: 10.1016/j.jneuroim.2017.10.002. Epub 2017 Oct 5.
10
Advanced glycation end products reduce the calcium transient in cardiomyocytes by increasing production of reactive oxygen species and nitric oxide.
FEBS Open Bio. 2017 Sep 26;7(11):1672-1685. doi: 10.1002/2211-5463.12284. eCollection 2017 Nov.
Zotero 插件