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指甲油中的甲醛。

Formaldehyde in "Nontoxic" Nail Polish.

机构信息

Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.

Department of Dermatology, University of Minnesota.

出版信息

Dermatitis. 2019 Jul/Aug;30(4):259-263. doi: 10.1097/DER.0000000000000493.

Abstract

BACKGROUND

Nail polish is known to contain potentially hazardous chemicals that have been linked to adverse health effects after overexposure. Formaldehyde is used as an antimicrobial, preservative, and nail hardener in select nail products, yet it is a recognized carcinogen and potent allergen in allergic contact dermatitis.

OBJECTIVE

The aim of this study was to investigate whether formaldehyde is present in nail polishes marketed as formaldehyde-free.

METHODS

Twenty-nine cosmetic nail polishes were purchased for analysis; of these, 28 were advertised as formaldehyde-free and/or did not declare formaldehyde in their ingredient lists. Initial testing was pursued using the chromotropic acid method, which uses a red-purple color change to indicate the presence of formaldehyde. Products were subsequently analyzed at least twice using high-performance liquid chromatography, quantifying formaldehyde amount above the detection limit of 2 ppm.

CONCLUSIONS

High-performance liquid chromatography analysis found 5 of 29 products containing formaldehyde, 4 of which were advertised as formaldehyde-free. All other products were negative for formaldehyde (<2 ppm). Further investigation is warranted among brands testing positive and whether multiple products within the same line contain formaldehyde. Nail products must be labeled appropriately to avoid adverse reactions among individuals with cutaneous sensitivities.

摘要

背景

指甲油中含有的潜在有害化学物质,在过度暴露后会对健康产生不良影响,这是已知的。甲醛被用作某些指甲产品中的抗菌剂、防腐剂和指甲硬化剂,但它是一种公认的致癌物质和变应原,会引起过敏性接触性皮炎。

目的

本研究旨在调查市场上宣传为无甲醛的指甲油中是否含有甲醛。

方法

购买了 29 种美容指甲油进行分析;其中 28 种被宣传为无甲醛,或在其成分清单中未声明含有甲醛。最初使用变色酸法进行测试,该方法使用红紫色颜色变化来指示甲醛的存在。随后使用高效液相色谱法至少对产品进行了两次分析,定量分析超过检测限 2ppm 的甲醛含量。

结论

高效液相色谱分析发现 29 种产品中有 5 种含有甲醛,其中 4 种被宣传为无甲醛。其他所有产品的甲醛含量均低于 2ppm(阴性)。需要对测试呈阳性的品牌以及同一产品线中的多个产品是否含有甲醛进行进一步调查。指甲产品必须正确标注,以避免皮肤敏感人群的不良反应。

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