年龄增长会对 CPAP 治疗嗅觉功能的疗效产生不利影响。
Increased age adversely affects the therapeutic effect of CPAP treatment for olfactory functions.
机构信息
Department of Otorhinolaryngology, Ankara Numune Training and Research Hospital, Talatpasa Avenue, 06230, Ankara, Turkey.
Sleep Disorders Center, Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital, 06280, Ankara, Turkey.
出版信息
Sleep Breath. 2020 Mar;24(1):83-88. doi: 10.1007/s11325-019-01889-1. Epub 2019 Jul 3.
PURPOSE
The aim of this study was to compare olfactory functions pre- and post-CPAP treatment in patients with moderate to severe OSA, and to evaluate the factors that cause changes in olfactory functions.
METHODS
Twenty-two patients who had completed regular usage of CPAP treatment for 2 months were included in this prospective study. Olfactory tests using Sniffin' Sticks were performed pre- and post-treatment.
RESULTS
The mean age of the subjects was 47.6 ± 9.5 years. We did not find a significant change in olfactory functions after 2 months of CPAP treatment in our study group. When the patients were divided into two groups-those whose olfactory functions showed improvement and those whose functions did not-it was found that the mean age of the patients whose olfactory functions did not improve was significantly higher statistically. A significant adverse correlation was found between age and post-treatment olfactory functions, specifically in odour threshold and odour identification scores.
CONCLUSIONS
Increased age adversely affects the therapeutic effect of CPAP treatment for olfactory functions.
目的
本研究旨在比较中重度阻塞性睡眠呼吸暂停（OSA）患者 CPAP 治疗前后的嗅觉功能，并评估导致嗅觉功能变化的因素。
方法
本前瞻性研究纳入了 22 例完成 CPAP 治疗 2 个月的患者。治疗前后采用 Sniffin' Sticks 进行嗅觉测试。
结果
研究对象的平均年龄为 47.6±9.5 岁。我们未发现 CPAP 治疗 2 个月后研究组患者嗅觉功能有显著变化。将患者分为嗅觉功能改善组和未改善组，发现嗅觉功能未改善组的患者平均年龄明显更高。年龄与治疗后嗅觉功能呈显著负相关，具体表现在气味阈值和气味识别评分上。
结论
年龄的增加会对 CPAP 治疗嗅觉功能的疗效产生不利影响。
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