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全腹腔镜活体供体右半肝切除术与开放手术的可行性比较:初始阶段 100 例的综合回顾。

Feasibility of total laparoscopic living donor right hepatectomy compared with open surgery: comprehensive review of 100 cases of the initial stage.

机构信息

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Department of General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.

出版信息

J Hepatobiliary Pancreat Sci. 2020 Jan;27(1):16-25. doi: 10.1002/jhbp.653. Epub 2019 Jul 24.

Abstract

BACKGROUND

This study analyzed the feasibility of laparoscopic living donor hepatectomy compared to open surgery.

METHODS

Donors who underwent living donor right from May 2013 to October 2017 were included. Comparisons between laparoscopy and open surgery were performed using Student's t-test, Mann-Whitney test, χ test, Fisher's exact test, and linear-by-linear association.

RESULTS

Among 305 donors, 100 and 205 underwent laparoscopy and open surgery, respectively. The laparoscopy group had more type I (95.0%) bile ducts than the open group (59.5%, P < 0.001) and had longer operation time (378.2 ± 93.5 min vs. 329.1 ± 68.0 min, P < 0.001), while estimated blood loss was smaller (298.3 ± 162.9 ml vs. 344.3 ± 149.9 ml, P = 0.015). Although Clavien-Dindo grade IIIb complication was higher in the laparoscopy (n = 4, 4.0%) compared to the open group (0.0%, P = 0.011), it was only significant in the initial 25 cases (8.0%, P = 0.011), and became comparable afterwards. Furthermore, grade IIIb complication was comparable when type I bile duct donors were selected (P = 0.072).

CONCLUSIONS

Laparoscopic living donor hepatectomy can cause significant complication in the initial stage. Therefore, careful donor selection and well-established training program are required for introducing the laparoscopic donor program.

摘要

背景

本研究分析了腹腔镜活体供肝切除术与开放手术相比的可行性。

方法

纳入 2013 年 5 月至 2017 年 10 月期间行活体供肝右肝切除术的供者。使用学生 t 检验、Mann-Whitney 检验、χ 检验、Fisher 确切概率检验和线性关联检验对腹腔镜与开放手术进行比较。

结果

在 305 名供者中,100 名和 205 名分别接受了腹腔镜和开放手术。腹腔镜组胆管Ⅰ型(95.0%)多于开放组(59.5%,P<0.001),手术时间更长(378.2±93.5min 比 329.1±68.0min,P<0.001),估计出血量更小(298.3±162.9ml 比 344.3±149.9ml,P=0.015)。尽管腹腔镜组(4 例,4.0%)IIIb 级并发症发生率高于开放组(0.0%,P=0.011),但仅在前 25 例中差异有统计学意义(8.0%,P=0.011),随后两组间差异无统计学意义。此外,当选择胆管Ⅰ型供者时,IIIb 级并发症发生率无差异(P=0.072)。

结论

腹腔镜活体供肝切除术在初期可能会引起严重的并发症。因此,需要仔细选择供者,并建立完善的培训计划,以开展腹腔镜供者项目。

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