强直性脊柱炎患者获得性纯红细胞再生障碍性贫血——一例报告及文献复习
Acquired pure red cell aplasia in a patient with ankylosing spondylitis- a case report and literature review.
作者信息
Shao Xianfang, Wei Wei, Zhao Yangzhi, Liang Xinyue, Liu Qiuju
机构信息
Hematology Section, Cancer Center.
Department of Urology, the First Hospital of Jilin University, Changchun, JL, China.
出版信息
Medicine (Baltimore). 2019 Jul;98(27):e16160. doi: 10.1097/MD.0000000000016160.
RATIONALE
Acquired pure red cell aplasia (PRCA) can be a secondary response to some autoimmune disorders. However, there is no data about the possibility of acquired PRCA being a secondary complication to ankylosing spondylitis (AS).
PATIENT CONCERNS
A 42-year-old male who had a history of AS for 14 years. He got serious anemia 17 months ago. Bone marrow smear indicated PRCA.
DIAGNOSE
He was diagnosed with acquired PRCA secondary to AS.
INTERVENTION
The combination treatment of immunosuppressants with hematopoiesis stimuli was successful.
OUTCOMES
The patient recovered from PRCA, and showed improvement in his AS.
LESSONS
Acquired PRCA can be secondary to AS. Cyclosporine is effective in controlling AS arthritis syndrome and in addition to immunosuppressants, promotion of erythroid hematopoiesis is equally important.
原理
获得性纯红细胞再生障碍性贫血（PRCA）可能是某些自身免疫性疾病的继发反应。然而，尚无关于获得性PRCA作为强直性脊柱炎（AS）继发并发症可能性的数据。
患者情况
一名42岁男性，有14年AS病史。17个月前出现严重贫血。骨髓涂片显示为PRCA。
诊断
他被诊断为继发于AS的获得性PRCA。
干预
免疫抑制剂与造血刺激剂联合治疗取得成功。
结果
患者从PRCA中康复，且AS病情有所改善。
经验教训
获得性PRCA可能继发于AS。环孢素在控制AS关节炎综合征方面有效，除免疫抑制剂外，促进红系造血同样重要。
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