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通过生命周期控制纳米增强产品的风险:以用于木材保护的纳米氧化铜涂料和用于汽车工业的纳米颜料为例。

Controlling the risks of nano-enabled products through the life cycle: The case of nano copper oxide paint for wood protection and nano-pigments used in the automotive industry.

机构信息

Department of Environmental Sciences, Informatics and Statistics, Ca' Foscari University of Venice, Via Torino 155, 30170 Mestre-Venezia, Italy.

TNO, Utrechtseweg 48, NL-3704 HE Zeist, the Netherlands.

出版信息

Environ Int. 2019 Oct;131:104901. doi: 10.1016/j.envint.2019.06.011. Epub 2019 Jul 4.

Abstract

The widespread use of engineered nanomaterials (ENMs) in consumer products and the overwhelming uncertainties in their ecological and human health risks have raised concerns regarding their safety among industries and regulators. There has been an ongoing debate over the past few decades on ways to overcome the challenges in assessing and mitigating nano-related risks, which has reached a phase of general consensus that nanotechnology innovation should be accompanied by the application of the precautionary principle and best practice risk management, even if the risk assessment uncertainties are large. We propose a quantitative methodology for selecting the optimal risk control strategy based on information about human health and ecological risks, efficacy of risk mitigation measures, cost and other contextual factors. The risk control (RC) methodology was developed in the European FP7 research project SUN and successfully demonstrated in two case studies involving real industrial nano-enabled products (NEPs): nano-scale copper oxide (CuO) and basic copper carbonate (Cu(OH)CO) used as antimicrobial and antifungal coatings and impregnations for the preservation of treated wood, and two nanoscale pigments used for colouring plastic automotive parts (i.e. red organic pigment and carbon black). The application of RC for human health risks showed that although nano-related risks could easily be controlled in automotive plastics case study with modifications in production technology or specific type of engineering controls, nano-related risks due to sanding and sawing copper oxide painted wood were non-acceptable in the use lifecycle stage and would need the identification of a more effective risk control strategy.

摘要

工程纳米材料(ENMs)在消费品中的广泛应用,以及其对生态和人类健康风险的巨大不确定性,引起了行业和监管机构对其安全性的关注。在过去几十年中,一直在争论如何克服评估和减轻纳米相关风险的挑战,目前已达成普遍共识,即纳米技术创新应伴随着应用预防原则和最佳实践风险管理,即使风险评估存在较大不确定性。我们提出了一种基于人类健康和生态风险、风险缓解措施的有效性、成本和其他背景因素的定量方法,用于选择最佳风险控制策略。该风险控制(RC)方法是在欧盟第七框架计划(FP7)研究项目 SUN 中开发的,并在涉及实际工业纳米增强产品(NEP)的两个案例研究中成功得到验证:纳米级氧化铜(CuO)和碳酸氢氧化铜(Cu(OH)CO)用作抗菌和抗真菌涂层和浸渍剂,以保存处理过的木材,以及两种用于着色塑料汽车零件的纳米级颜料(即红色有机颜料和炭黑)。RC 对人类健康风险的应用表明,尽管在汽车塑料案例研究中通过修改生产技术或特定类型的工程控制很容易控制与纳米相关的风险,但在使用生命周期阶段,由于打磨和锯切氧化铜涂漆木材而产生的与纳米相关的风险是不可接受的,需要确定更有效的风险控制策略。

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