Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Biosens Bioelectron. 2019 Oct 1;142:111484. doi: 10.1016/j.bios.2019.111484. Epub 2019 Jul 2.
Early stage detection of prostate cancer, one of the main causes of mortality among men, is of great importance for better treatment of the patients. Prostate specific antigen (PSA) is a glycoprotein which has been considered as the most potential serological biomarker for the detection of prostate cancer. Among the various techniques employed for PSA detection, aptamer-based biosensors (aptasensors) have achieved notable attention because of their unique features and great potentials as diagnostic tools. A variety of strategies such as integration of nanomaterials (NMs) into the structure of aptasensors have also been applied for enhancing the sensitivity of PSA detection. This article reviews recent advances in various optical and electrochemical aptasensors used for PSA detection.
早期检测前列腺癌是降低男性死亡率的关键，前列腺特异抗原（PSA）是一种糖蛋白，被认为是前列腺癌检测最有潜力的血清生物标志物。在用于 PSA 检测的各种技术中，适配体生物传感器（aptasensors）因其独特的特性和作为诊断工具的巨大潜力而受到广泛关注。为了提高 PSA 检测的灵敏度，人们还应用了各种策略，例如将纳米材料（NMs）整合到 aptasensors 的结构中。本文综述了用于 PSA 检测的各种光学和电化学 aptasensors 的最新进展。
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