在瑞士检测到 NDM-19，这是一种新型新德里金属β-内酰胺酶，在锌受限条件下具有增强的碳青霉烯酶活性。
Detection of NDM-19, a novel variant of the New Delhi metallo-β-lactamase with increased carbapenemase activity under zinc-limited conditions, in Switzerland.
机构信息
University of Zurich, Institute of Medical Microbiology, Zurich, Switzerland.
University of Zurich, Institute of Medical Microbiology, Zurich, Switzerland.
出版信息
Diagn Microbiol Infect Dis. 2019 Nov;95(3):114851. doi: 10.1016/j.diagmicrobio.2019.06.003. Epub 2019 Jun 15.
A novel New Delhi metallo-β-lactamase (NDM) variant, NDM-19, was identified in a carbapenem-resistant E. coli strain isolated from a subcutaneous infection of a laparotomy scar from an Egyptian patient in a Swiss hospital. NDM-19 is a derivative of NDM-7, from which it differs by a single amino acid substitution (Ala233Val). Under zinc-limiting growth conditions, E. coli DH5α transformants producing NDM-19 displayed reduced susceptibility towards expanded-spectrum cephalosporins and carbapenems as compared to transformants producing NDM-1 or NDM-7.
一种新型的新德里金属β-内酰胺酶（NDM）变体 NDM-19 在瑞士一家医院从埃及患者的剖腹手术后疤痕处的耐碳青霉烯类大肠杆菌菌株中被发现。NDM-19 是 NDM-7 的衍生物，两者仅在一个氨基酸（丙氨酸 233 到缬氨酸）上有所不同。在锌限制生长条件下，与产生 NDM-1 或 NDM-7 的转化体相比，产生 NDM-19 的大肠杆菌 DH5α 转化体对扩展谱头孢菌素类和碳青霉烯类的敏感性降低。
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