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非洲国家的胸外科医生如何处理气管肿瘤?(病例系列)

How thoracic surgeon manage tracheal tumors in African country? (Case series).

作者信息

Rabiou Sani, Alami Badredine, Efared Boubacar, Lakranbi Marwane, Harmouchi Hicham, El-Amrani Rim, Serraj Mounia, El-Bouazzaoui Abderrahim, Ouadnouni Yassine, Kanja Nabil, Smahi Mohamed

机构信息

Department of Thoracic Surgery, CHU Hassan II, Fez, Morocco.

Faculty of Medicine and Pharmacy, Université de Niamey, Niger.

出版信息

Ann Med Surg (Lond). 2019 Jun 18;44:13-19. doi: 10.1016/j.amsu.2019.06.007. eCollection 2019 Aug.

Abstract

INTRODUCTION

Tracheal tumors are a rare pathological entity whose diagnosis is usually delayed by clinical latency. Surgery, which consists of a tracheal resection-anastomosis with or without reconstructive reconstruction, remains the treatment that ensures the best long-term survival.

METHODS

This is a retrospective study about 8 patients admitted in the department of thoracic surgery of Hassan II's university hospital of Fes for tracheal tumors management during 7 years time (December 2010 to December 2017).

RESULTS

There were 6 men and 2 women with an average age of 44.4 years ranged from 17 to 65 years, 4 were smokers. Dyspnea was the main trigger sign. Seven (7) have undergone bronchial fibroscopy diagnostic with a finding of budding process in 5 patients, the middle of the trachea is often concerned in 3 patients, obstructing the lumen of the trachea in almost all patients. The treatment in all patients was surgical with an intubation via the operative field, 4 trachea resection-anastomosis, 4 plasty (Lateral resection with V plasty, Kergin's plasty, Mattey's tracheobronchial anastomosis and widened V-resection to the carina). The most common histological type in our series was Adenoid Cystic Carcinoma in 2 of our patients. For the other patients we have found squamous cell carcinoma (1 case), adenocarcinoma (1 case), atypical carcinoid tumor (1 case), low grade mucoepidermoid carcinoma (1 case), an adenoma pleomorph (1 case) and endotracheal goiter (1 case). The operative follow-up was simple in 7 of our patients, all of whom underwent post-operative fibroscopy within an average of 9 days. Two cases of post-operative recurrent palsy had been observed, all of which had progressed well under treatment. We have noted 2 deaths, including one at day 4 post-operative, and the other died from complications of post-radiation tracheal stenosis. Back to 32 months' average follow-up, we have enregistered a case of a distant relapse by cervical lymph node metastasis in one patient, 5 years after surgery.

CONCLUSION

Primary tumors of the trachea remain of reserved prognosis with 5-year survival of 57% of all histological types combined. Computed tomodensitometry and tracheobronchial fibroscopy remain the means of reference exploration in the diagnosis and assessment of surgical resectability.

摘要

引言

气管肿瘤是一种罕见的病理实体,其诊断通常因临床潜伏期而延迟。手术,包括气管切除-吻合术(有无重建),仍然是确保最佳长期生存的治疗方法。

方法

这是一项回顾性研究,研究对象为7年间(2010年12月至2017年12月)在非斯哈桑二世大学医院胸外科收治的8例气管肿瘤患者。

结果

6例男性,2例女性,平均年龄44.4岁,年龄范围为17至65岁,4例为吸烟者。呼吸困难是主要触发症状。7例患者接受了支气管纤维镜检查诊断,5例发现有芽生过程,3例常累及气管中部,几乎所有患者气管腔均有阻塞。所有患者均接受手术治疗,术中通过手术视野插管,4例行气管切除-吻合术,4例行整形手术(外侧切除加V形整形、克尔金整形、马蒂气管支气管吻合术和向隆突扩大V形切除)。我们系列中最常见的组织学类型是腺样囊性癌,有2例患者。其他患者中,我们发现了鳞状细胞癌(1例)、腺癌(1例)、非典型类癌肿瘤(1例)、低级别黏液表皮样癌(1例)、多形性腺瘤(1例)和气管内甲状腺肿(1例)。7例患者的手术随访简单,所有患者平均在术后9天内接受了纤维镜检查。观察到2例术后复发性麻痹,均在治疗下进展良好。我们记录了2例死亡,其中1例在术后第4天死亡,另1例死于放疗后气管狭窄并发症。在平均32个月的随访中,我们记录了1例患者在术后5年出现远处复发,发生颈部淋巴结转移。

结论

气管原发性肿瘤预后仍然不佳,所有组织学类型合并后的5年生存率为57%。计算机断层扫描和气管支气管纤维镜检查仍然是诊断和评估手术可切除性的参考检查手段。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9994/6593208/7a3215c70417/gr1.jpg

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