NHC Key Laboratory of Carcinogenesis (Central South University) and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.
Cell Mol Life Sci. 2019 Nov;76(21):4275-4289. doi: 10.1007/s00018-019-03222-1. Epub 2019 Jul 15.
Numerous studies have shown that non-coding RNAs play crucial roles in the development and progression of various tumor cells. Plasmacytoma variant translocation 1 (PVT1) mainly encodes a long non-coding RNA (lncRNA) and is located on chromosome 8q24.21, which constitutes a fragile site for genetic aberrations. PVT1 is well-known for its interaction with its neighbor MYC, which is a qualified oncogene that plays a vital role in tumorigenesis. In the past several decades, increasing attention has been paid to the interaction mechanism between PVT1 and MYC, which will benefit the clinical treatment and prognosis of patients. In this review, we summarize the coamplification of PVT1 and MYC in cancer, the positive feedback mechanism, and the latest promoter competition mechanism of PVT1 and MYC, as well as how PVT1 participates in the downstream signaling pathway of c-Myc by regulating key molecules. We also briefly describe the treatment prospects and research directions of PVT1 and MYC.
大量研究表明，非编码 RNA 在各种肿瘤细胞的发生和发展中发挥着关键作用。浆细胞瘤变异易位 1（PVT1）主要编码长链非编码 RNA（lncRNA），位于染色体 8q24.21，是遗传异常的脆性位点。PVT1 以与相邻 MYC 的相互作用而闻名，MYC 是一种合格的癌基因，在肿瘤发生中起着至关重要的作用。在过去的几十年中，人们越来越关注 PVT1 和 MYC 之间的相互作用机制，这将有利于患者的临床治疗和预后。在这篇综述中，我们总结了 PVT1 和 MYC 在癌症中的共扩增、正反馈机制以及 PVT1 和 MYC 的最新启动子竞争机制，以及 PVT1 如何通过调节关键分子参与 c-Myc 的下游信号通路。我们还简要描述了 PVT1 和 MYC 的治疗前景和研究方向。
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