儿童成釉细胞瘤的复发因素：临床特征和一种新的分类系统。
Recurrence factors in pediatric ameloblastoma: Clinical features and a new classification system.
机构信息
Department of Oral Maxillofacial-Head Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Stomatology, Tongren Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
出版信息
Head Neck. 2019 Oct;41(10):3491-3498. doi: 10.1002/hed.25867. Epub 2019 Jul 19.
BACKGROUND
Ameloblastomas of jaw in the pediatric population are a rare clinical entity and have not been well addressed in the literatures. The present retrospective study analyzed the risk factors associated with recurrence of pediatric ameloblastomas.
METHODS
Cases of primary pediatric ameloblastomas seen in a tertiary hospital between 2005 and 2015 were analyzed to identify the clinical factors associated with recurrence.
RESULTS
There were a total of 104 cases of primary pediatric ameloblastomas. The overall mean maximum tumor diameter was 4.11 ± 1.339 cm. The receiver operating characteristic curve and the Youden Index showed an optimal cutoff point of 4.95 cm to accurately predict recurrence. Bone cortex/soft tissue invasion were associated with tumor recurrence (P < .001).
CONCLUSIONS
The maximum tumor diameter, root resorption, and bone cortex/soft tissue invasion were risk factors for recurrence of pediatric ameloblastomas. The new classification system may serve as a predictor of recurrence in pediatric ameloblastomas.
背景
儿童颌骨造釉细胞瘤是一种罕见的临床实体，在文献中尚未得到很好的描述。本回顾性研究分析了与儿童造釉细胞瘤复发相关的危险因素。
方法
分析了 2005 年至 2015 年期间在一家三级医院就诊的原发性儿童造釉细胞瘤病例，以确定与复发相关的临床因素。
结果
共 104 例原发性儿童造釉细胞瘤。总的平均最大肿瘤直径为 4.11±1.339cm。受试者工作特征曲线和 Youden 指数显示，最佳截断值为 4.95cm，可以准确预测复发。骨皮质/软组织侵犯与肿瘤复发相关（P<0.001）。
结论
最大肿瘤直径、牙根吸收和骨皮质/软组织侵犯是儿童造釉细胞瘤复发的危险因素。新的分类系统可能是儿童造釉细胞瘤复发的预测因子。
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