Weiss R A, Clapham P R, Weber J N, Whitby D, Tedder R S, O'Connor T, Chamaret S, Montagnier L
Chester Beatty Laboratories, Institute of Cancer Research, London, UK.
AIDS. 1988 Apr;2(2):95-100. doi: 10.1097/00002030-198804000-00004.
The neutralization properties of three independent HIV-2 isolates were examined in comparison with four diverse HIV-1 strains. Human sera containing antibodies specific to HIV-2 can cross-neutralize HIV-1. By contrast, HIV-1 sera are group-specific and have no neutralizing effect on HIV-2. Therefore, HIV-2 antigens may be important components for the development of broadly cross-protective AIDS vaccines.
与四种不同的HIV-1毒株相比,研究了三种独立的HIV-2分离株的中和特性。含有HIV-2特异性抗体的人血清可以交叉中和HIV-1。相比之下,HIV-1血清具有群特异性,对HIV-2没有中和作用。因此,HIV-2抗原可能是开发具有广泛交叉保护作用的艾滋病疫苗的重要成分。