School of Chemical and Physical Sciences, Victoria University of Wellington, Wellington 6012, New Zealand.
Centre for Biodiscovery, Victoria University of Wellington, Wellington 6012, New Zealand.
Mar Drugs. 2019 Jul 19;17(7):418. doi: 10.3390/md17070418.
Red algae of the genus have been a rich source of halogenated monoterpenes. Herein, a new cyclic monoterpene, costatone C (), was isolated from the extract of collected in New Zealand, along with the previously reported (1,5)-1,6-dichloro-2-methylhepta-1,5-dien-3-ol (). Elucidation of the planar structure of was achieved through conventional NMR and (-)-HR-APCI-MS techniques, and the absolute configuration by comparison of experimental and DFT-calculated ECD spectra. The absolute configuration of was determined using Mosher's method. Compound showed mild antibacterial activity against and . The state of taxonomy and its implications upon natural product distributions, especially across samples from specimens collected in different countries, is also discussed.
红藻属的植物一直是卤代单萜的丰富来源。在此，从新西兰采集的提取物中分离得到一种新的环状单萜，即 costatone C（），同时还分离得到了先前报道的（1,5）-1,6-二氯-2-甲基庚-1,5-二烯-3-醇（）。通过常规 NMR 和 (-)-HR-APCI-MS 技术阐明了 的平面结构，并通过比较实验和 DFT 计算的 ECD 光谱确定了其绝对构型。使用 Mosher 法确定了 的绝对构型。化合物 对 和 表现出温和的抗菌活性。还讨论了 的分类状态及其对天然产物分布的影响，特别是对来自不同国家采集的标本的影响。
