Department of Orthopaedic Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan Province, 610041, China.
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Curr Gene Ther. 2019;19(4):255-263. doi: 10.2174/1566523219666190716092203.
Osteoarthritis (OA) is a disease characterized by progressive degeneration, joint hyperplasia, narrowing of joint spaces, and extracellular matrix metabolism. Recent studies have shown that the pathogenesis of OA may be related to non-coding RNA, and its pathological mechanism may be an effective way to reduce OA.
The purpose of this review was to investigate the recent progress of miRNA, long noncoding RNA (lncRNA) and circular RNA (circRNA) in gene therapy of OA, discussing the effects of this RNA on gene expression, inflammatory reaction, apoptosis and extracellular matrix in OA.
The following electronic databases were searched, including PubMed, EMBASE, Web of Science, and the Cochrane Library, for published studies involving the miRNA, lncRNA, and circRNA in OA. The outcomes included the gene expression, inflammatory reaction, apoptosis, and extracellular matrix.
With the development of technology, miRNA, lncRNA, and circRNA have been found in many diseases. More importantly, recent studies have found that RNA interacts with RNA-binding proteins to regulate gene transcription and protein translation, and is involved in various pathological processes of OA, thus becoming a potential therapy for OA.
In this paper, we briefly introduced the role of miRNA, lncRNA, and circRNA in the occurrence and development of OA and as a new target for gene therapy.
骨关节炎（OA）是一种以进行性退变、关节增生、关节间隙变窄和细胞外基质代谢为特征的疾病。最近的研究表明，OA 的发病机制可能与非编码 RNA 有关，其病理机制可能是减少 OA 的有效途径。
本综述旨在探讨 miRNA、长链非编码 RNA（lncRNA）和环状 RNA（circRNA）在 OA 基因治疗中的最新进展，讨论这些 RNA 对 OA 中基因表达、炎症反应、细胞凋亡和细胞外基质的影响。
检索了以下电子数据库：PubMed、EMBASE、Web of Science 和 Cochrane Library，以获取涉及 OA 中 miRNA、lncRNA 和 circRNA 的已发表研究。结果包括基因表达、炎症反应、细胞凋亡和细胞外基质。
随着技术的发展，miRNA、lncRNA 和 circRNA 在许多疾病中都有发现。更重要的是，最近的研究发现，RNA 与 RNA 结合蛋白相互作用，调节基因转录和蛋白质翻译，并参与 OA 的各种病理过程，从而成为 OA 的一种潜在治疗方法。
本文简要介绍了 miRNA、lncRNA 和 circRNA 在 OA 的发生发展中的作用以及作为基因治疗的新靶点。
