University Children's Hospital Augsburg, Swabian Children's Cancer Center, Augsburg, Germany.
Institute of Human Genetics, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.
Pediatr Blood Cancer. 2019 Nov;66(11):e27916. doi: 10.1002/pbc.27916. Epub 2019 Jul 24.
Approximately 10% of all children with cancer are affected by a monogenic cancer predisposition syndrome. This has important implications for both the child and her/his family. The assessment of hereditary cancer predisposition is a challenging task for clinicians and genetic counselors in daily routine. It includes consideration of tumor genetics, specific features of the patient, and the medical/family history. To keep up with the pace of this rapidly evolving and increasingly complex field of genetic susceptibility, we suggest a systematic approach for the evaluation of the child with cancer and her/his family by an interdisciplinary team specialized in hereditary cancer predisposition.
约 10%的癌症儿童受到单基因癌症易感性综合征的影响。这对孩子及其家庭都有重要影响。遗传性癌症易感性的评估是临床医生和遗传咨询师日常工作中的一项具有挑战性的任务。它包括考虑肿瘤遗传学、患者的特定特征以及医疗/家族史。为了跟上这个快速发展且日益复杂的遗传易感性领域的步伐，我们建议由专门研究遗传性癌症易感性的跨学科团队对患有癌症的儿童及其家庭进行系统评估。
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