探讨趋化因子受体家族在胃癌中的预后价值。
Characterization of the prognostic values of CXCR family in gastric cancer.
机构信息
Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200025, PR China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200025, PR China; Department of Gastrointestinal Surgery, Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 20025, PR China.
Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College in Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
出版信息
Cytokine. 2019 Nov;123:154785. doi: 10.1016/j.cyto.2019.154785. Epub 2019 Jul 22.
INTRODUCTION
The role of CXC chemokine receptors (CXCRs) in gastric cancer (GC) has been an increasing focus. However, comprehensive prognostic values of CXCR members in GC are yet to be clearly defined.
METHODS
Multiple public available datasets, including Kaplan-Meier (KM) plotter, oncomine, the cancer genome atlas (TCGA), SurvExpress platform and the tumor immune estimation resource (TIMER), were used for mRNA expression and prognostic characterization. Nomogram method was used for clinical model prediction.
RESULTS
CXCR3, CXCR4 and CXCR5 displayed significantly up-regulated expression in tumor compared to normal. High mRNA expression of CXCR2 (HR = 0.77, 95%CI: 0.62-0.95, p = 0.014), CXCR3 (HR = 0.74, 95%CI: 0.61-0.90, p = 0.0024), CXCR4 (HR = 0.7, 95%CI: 0.58-0.86, p = 0.00048), CXCR5 (HR = 0.72, 95%CI: 0.59-0.87, p = 0.00093) and CXCR6 (HR = 0.66, 95%CI: 0.54-0.81, p = 4.9e-05) was significantly associated with favorable overall survival (OS). The prognostic values of CXCR members were also explored in subtypes, including HER2 status, Lauren classification, pathological stages. The low risk group of CXCR signature displayed a significantly favorable OS compared to the high risk group (HR = 3.22, 95% CI = 2.21-4.69, p = 1.057e-09). Nomogram clinical models were established for both OS (C-index: 0.692; 95%CI: 0.648-0.736) and recurrence free survival (C-index: 0.731; 95%CI: 0.675-0.786). In addition, CXCR6 and CD8+T cells featured the highest correlation (partial-cor = 0.781, p = 4.17e-77).
CONCLUSION
This study identified distinct expression and prognostic values of CXCR members in GC using public databases.
简介
趋化因子 CXC 受体（CXCRs）在胃癌（GC）中的作用备受关注。然而，CXCR 成员在 GC 中的全面预后价值仍有待明确界定。
方法
本研究使用多个公共可用数据集，包括 Kaplan-Meier（KM）绘图仪、Oncomine、癌症基因组图谱（TCGA）、SurvExpress 平台和肿瘤免疫评估资源（TIMER），用于分析 mRNA 表达和预后特征。采用列线图方法进行临床模型预测。
结果
与正常组织相比，肿瘤中 CXCR2、CXCR3、CXCR4 和 CXCR5 的 mRNA 表达明显上调。高表达的 CXCR2（HR=0.77，95%CI：0.62-0.95，p=0.014）、CXCR3（HR=0.74，95%CI：0.61-0.90，p=0.0024）、CXCR4（HR=0.7，95%CI：0.58-0.86，p=0.00048）、CXCR5（HR=0.72，95%CI：0.59-0.87，p=0.00093）和 CXCR6（HR=0.66，95%CI：0.54-0.81，p=4.9e-05）与总生存（OS）的改善显著相关。还在包括 HER2 状态、Lauren 分类、病理分期在内的亚型中探索了 CXCR 成员的预后价值。与高风险组相比，CXCR 特征的低危组显示出显著改善的 OS（HR=3.22，95%CI=2.21-4.69，p=1.057e-09）。为 OS（C 指数：0.692；95%CI：0.648-0.736）和无复发生存（C 指数：0.731；95%CI：0.675-0.786）建立了列线图临床模型。此外，CXCR6 和 CD8+T 细胞的相关性最高（偏相关系数=0.781，p=4.17e-77）。
结论
本研究使用公共数据库鉴定了 GC 中 CXCR 成员的独特表达和预后价值。
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