Hasnain Huma, Afif Nawal, Nicholas Susanne B
Division of Nephrology, Department of Medicine, David Geffen School of Medicine at UCLA, USA.
J Clin Nephrol Ren Care. 2018;4(2). doi: 10.23937/2572-3286.1510040. Epub 2018 Dec 20.
Renal artery dissections (RADs) are lesions that disrupt vessels that primarily occur in patients with a known history of hypertension and caused by stenosis or enlargement of the renal artery typically due to underlying connective tissue disorders. However, RADs may occur spontaneously from trauma and no previous history of hypertension. Here, we report a rare case of bilateral isolated spontaneous RADs that characteristically occurs in healthy males. A 52-year-old male presented with left lower quadrant abdominal pain and renal insufficiency. Two years prior, he had experienced a similar episode of pain on the contralateral side, which was due to an infarct of the right kidney. On this admission, a computed tomography angiogram confirmed a new infarct of the left kidney, with dissection of a branch of the renal artery supplying the upper lobe. Work-up for cardiovascular, hematologic, radiographic or connective tissue causes was negative. We postulate that both RADs were potentially associated with the rapid twisting and turning of the abdominal area on a daily basis required for his occupation as an air traffic controller. The patient was treated with a renin angiotensin system inhibitor. After one year, both RADs had significantly improved and his renal function increased by ~23%. Isolated RAD may be associated with consistent or long-term activities that require rapid twisting and turning of the abdominal area. If left untreated, this may result in malignant hypertension, bilateral dissections, or renal ischemia. To avoid misdiagnosis; we provide a comprehensive review of the typical presentation and necessary assessment and management.
肾动脉夹层(RADs)是一种破坏血管的病变,主要发生在有高血压病史的患者中,通常由潜在的结缔组织疾病导致肾动脉狭窄或扩张引起。然而,RADs也可能因外伤自发发生,且患者既往无高血压病史。在此,我们报告一例罕见的双侧孤立性自发性RADs病例,其典型发生于健康男性。一名52岁男性因左下象限腹痛和肾功能不全就诊。两年前,他曾在对侧经历过类似的疼痛发作,原因是右肾梗死。此次入院时,计算机断层血管造影证实左肾有新的梗死灶,供应上叶的肾动脉分支有夹层。对心血管、血液学、影像学或结缔组织病因的检查均为阴性。我们推测,这两个RADs可能都与他作为空中交通管制员的职业每天所需的腹部快速扭转和转动有关。患者接受了肾素血管紧张素系统抑制剂治疗。一年后,两个RADs均有显著改善,其肾功能提高了约23%。孤立性RAD可能与需要腹部快速扭转和转动的持续或长期活动有关。如果不治疗,这可能导致恶性高血压、双侧夹层或肾缺血。为避免误诊,我们对典型表现以及必要的评估和管理进行了全面综述。