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脉络膜痣旁的黑色素瘤相关海绵状巩膜病变

Melanoma-Associated Spongiform Scleropathy Adjacent to a Choroidal Nevus.

作者信息

Schneider Alexander, Pavan Peter R, Margo Curtis E, Bajric Jasmina

机构信息

Morsani College of Medicine, Department of Ophthalmology, University of South Florida, Tampa, Florida, USA.

Morsani College of Medicine, Department of Pathology and Cell Biology, University of South Florida, Tampa, Florida, USA.

出版信息

Ocul Oncol Pathol. 2019 Jun;5(4):258-261. doi: 10.1159/000494326. Epub 2018 Dec 19.

Abstract

Melanoma-associated spongiform scleropathy contiguous to a choroidal nevus was an incidental finding in a 57-year-old woman whose eye was removed for a separate choroidal-ciliary body melanoma. All previously reported cases of melanoma-associated spongiform scleropathy, except for one, have been found adjacent to posterior uveal melanoma. The mechanism of scleral degeneration in melanoma-associated spongiform scleropathy is unknown. Few cases of posterior uveal nevi have been reported since the description of spongiform scleropathy, making assessment of the specificity of the degeneration to melanoma alone difficult. The presence of melanoma-associated scleropathy adjacent to a choroidal nevus indicates that the condition is not exclusively linked to posterior uveal melanoma.

摘要

一名57岁女性因另发的脉络膜 - 睫状体黑色素瘤而摘除眼球,术中偶然发现与脉络膜痣相邻的黑色素瘤相关海绵状巩膜病变。除1例之外,所有先前报道的黑色素瘤相关海绵状巩膜病变病例均发现于后葡萄膜黑色素瘤附近。黑色素瘤相关海绵状巩膜病变中巩膜变性的机制尚不清楚。自海绵状巩膜病变被描述以来,后葡萄膜痣的病例报道较少,这使得仅评估该变性对黑色素瘤的特异性变得困难。与脉络膜痣相邻存在黑色素瘤相关巩膜病变表明,这种情况并非仅与后葡萄膜黑色素瘤有关。

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本文引用的文献

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Estimating the risk of malignant transformation of a choroidal nevus.评估脉络膜痣恶变的风险。
Ophthalmology. 2005 Oct;112(10):1784-9. doi: 10.1016/j.ophtha.2005.06.011.
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