白塞病患者心血管风险增加和全因死亡：一项韩国全国基于人群的动态队列研究。
Increased Cardiovascular Risk and All-cause Death in Patients with Behçet Disease: A Korean Nationwide Population-based Dynamic Cohort Study.
机构信息
From the Departments of Cardiology and Dermatology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea; Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea; Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
H.S. Ahn, MD, PhD, Associate Professor, Department of Cardiology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea; D. Lee, MD, Assistant Professor, Department of Cardiology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea; S.Y. Lee, MD, Department of Dermatology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea; Y.H. Kim, MD, Department of Dermatology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea; J.H. Lee, MD, PhD, Assistant Professor, Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea; D.S. Yu, MD, PhD, Professor, Department of Dermatology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea; K. Han, PhD, Department of Biostatistics, College of Medicine, The Catholic University of Korea; Y.G. Park, PhD, Professor, Department of Biostatistics, College of Medicine, The Catholic University of Korea; Y.B. Lee, MD, PhD, Assistant Professor, Department of Dermatology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea.
出版信息
J Rheumatol. 2020 Jun 1;47(6):903-908. doi: 10.3899/jrheum.190408. Epub 2019 Aug 1.
OBJECTIVE
Behçet disease (BD) is a chronic inflammatory multiorgan disease. An increased risk of cardiovascular disease (CVD) and heightened death rate with BD have been suggested, but to our knowledge, a nationwide large-scale study has not been conducted to date. This study aimed to determine the overall CV risk and death rate in patients with BD versus controls using the Korean National Health Insurance Service claim database.
METHODS
Patients with BD (n = 5576) with no previous history of CVD were selected from 2010 to 2014. An age- and sex-matched control population of individuals without BD (n = 27,880) was randomly sampled at a ratio of 5:1. Both cohorts were followed for incident CVD or all-cause death until 2015.
RESULTS
The risks of myocardial infarction (HR 1.72, 95% CI 1.01-2.73) and stroke (HR 1.65, 95% CI 1.09-2.50) were significantly higher in patients with BD than in controls. Patients with BD also had a significantly higher risk of all-cause death (HR 1.82, 95% CI 1.40-2.37) compared to controls.
CONCLUSION
Korean patients with BD had a higher overall risk of CVD than did those without BD. Therefore, patients with BD must be carefully monitored for the potential development of CVD to ensure that appropriate early treatments are delivered.
目的
白塞病（BD）是一种慢性炎症性多系统疾病。已有研究提示该病存在心血管疾病（CVD）风险增加和死亡率升高，但据我们所知，目前尚未开展全国范围内的大规模研究。本研究旨在利用韩国国家健康保险服务索赔数据库，确定 BD 患者与对照组患者的总体心血管风险和死亡率。
方法
本研究从 2010 年至 2014 年选取了 5576 例无 CVD 既往史的 BD 患者。按照 5:1 的比例，随机选取了 27880 例无 BD 的年龄和性别匹配的对照组个体。对两组患者进行了 CVD 事件或全因死亡的随访，随访时间截止至 2015 年。
结果
与对照组相比，BD 患者发生心肌梗死（HR 1.72，95%CI 1.01-2.73）和中风（HR 1.65，95%CI 1.09-2.50）的风险显著升高。BD 患者的全因死亡率（HR 1.82，95%CI 1.40-2.37）也显著高于对照组。
结论
与无 BD 者相比，韩国 BD 患者的总体 CVD 风险更高。因此，必须密切监测 BD 患者潜在 CVD 的发生，以确保及时进行适当的早期治疗。
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