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2018 年 7 月,从一名尿路感染住院患者中分离出产碳青霉烯酶 KPC 和 TEM 的 ST131:意大利中部莫利塞地区的首次分离。

Carbapenem-Resistant KPC- and TEM-Producing ST131 Isolated from a Hospitalized Patient with Urinary Tract Infection: First Isolation in Molise Region, Central Italy, July 2018.

机构信息

Department of Medicine and Health Sciences "Vincenzo Tiberio," University of Molise, Campobasso, Italy.

Laboratory Medicine Unit, "Antonio Cardarelli" Hospital, Azienda Sanitaria Regionale del Molise, Campobasso, Italy.

出版信息

Microb Drug Resist. 2020 Jan;26(1):38-45. doi: 10.1089/mdr.2019.0085. Epub 2019 Aug 6.

Abstract

In July 2018, a carbapenemase (KPC)-producing ST131 was isolated from a patient admitted to the Vascular Surgery Unit of the main hospital of Molise region, Central Italy. Sequencing and alignment with the available sequences revealed that the isolate harbored the KPC-2 variant and TEM-1 beta-lactamase. This observation raises great concerns about the spread of carbapenem resistance in national and local settings with high endemicity level of KPC in , and underlines the importance of strengthening a proactive surveillance.

摘要

2018 年 7 月,从中意大利莫利塞地区主要医院的血管外科病房的一名患者身上分离出一株产碳青霉烯酶(KPC)的 ST131。测序并与现有序列比对显示,该分离株携带 KPC-2 变体和 TEM-1 贝塔内酰胺酶。这一观察结果令人对全国和地方范围内的碳青霉烯类耐药性传播感到极大担忧,这些地区的 KPC 流行水平较高,这突显了加强主动监测的重要性。

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