Department of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9040, USA.
Department of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9040, USA.
Dev Cell. 2019 Aug 5;50(3):264-282. doi: 10.1016/j.devcel.2019.06.003.
The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in an increasing number of human diseases, including cancer. Here, we provide an updated review of the Hippo pathway; discuss its roles in development, homeostasis, regeneration, and diseases; and highlight outstanding questions for future investigation and opportunities for Hippo-targeted therapies.
Hippo 信号通路调节多种生理过程,其功能障碍与越来越多的人类疾病有关,包括癌症。本文对 Hippo 通路进行了更新,讨论了其在发育、稳态、再生和疾病中的作用,并强调了未来研究的悬而未决的问题和 Hippo 靶向治疗的机会。