Morris D D, Messick J, Whitlock R H, Palmer J, Ward M V, Feldman B F
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Kennett Square 19348.
Am J Vet Res. 1988 Jul;49(7):1030-6.
Hemostatic function was determined in 10 ponies at various times after inoculation with Ehrlichia risticii to determine whether equine ehrlichial colitis (EEC) caused changes in the hemostatic system and to determine the prognostic value of hemostatic function tests during EEC. Mean platelet count; plasma fibrinogen, fibronectin, factor VIII: coagulant, alpha 2-antiplasmin, and plasminogen values; and serum concentrations of fibrin/fibrinogen degradation products changed significantly (P less than 0.05) from base line (day 0, before inoculation) during 18 days after inoculation with E risticii. Four ponies that died or were euthanatized because of severe clinical signs of EEC had significantly (P less than 0.05) greater mean plasma fibrinogen concentrations plasma factor VIII:coagulant values, and activated partial thromboplastin times immediately before death than did the 6 surviving ponies. Factor V concentrations were significantly (P less than 0.05) lower on postinoculation days 10 and 20 in nonsurvivors. Seemingly, changes in hemostasis took place during EEC. Ponies that did not survive EEC had greater laboratory evidence of coagulopathy.
在10匹小马接种瑞氏埃立克体后的不同时间测定止血功能，以确定马埃立克体性结肠炎（EEC）是否会引起止血系统的变化，并确定EEC期间止血功能测试的预后价值。接种瑞氏埃立克体后18天内，平均血小板计数、血浆纤维蛋白原、纤连蛋白、凝血因子VIII：凝血活性、α2 - 抗纤溶酶和纤溶酶原值以及纤维蛋白/纤维蛋白原降解产物的血清浓度与基线（接种前第0天）相比有显著变化（P < 0.05）。因EEC严重临床症状死亡或安乐死的4匹小马在死亡前的平均血浆纤维蛋白原浓度、血浆凝血因子VIII：凝血活性值和活化部分凝血活酶时间显著（P < 0.05）高于6匹存活的小马。非存活者在接种后第10天和第20天的凝血因子V浓度显著（P < 0.05）较低。显然，EEC期间发生了止血变化。未在EEC中存活的小马有更多的凝血病实验室证据。
