两亲性树枝状大分子与左氧氟沙星的协同抗菌作用。
Synergistic Effects of Anionic/Cationic Dendrimers and Levofloxacin on Antibacterial Activities.
机构信息
Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-236 Lodz, Poland.
CNRS, LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, BP 44099, F-31077 Toulouse CEDEX 4, France.
出版信息
Molecules. 2019 Aug 9;24(16):2894. doi: 10.3390/molecules24162894.
Despite the numerous studies on dendrimers for biomedical applications, the antibacterial activity of anionic phosphorus dendrimers has not been explored. In our research, we evaluated the antibacterial activity of modified polycationic and polyanionic dendrimers in combination with levofloxacin (LVFX) against Gram-negative ( ATCC 25922, ATCC 15442) and Gram-positive ( ATCC 6538) bacteria. In the case of Gram-negative bacteria, we concluded that a combination of dendrimers and antibiotic gave satisfactory results due to a synergistic effect. The use of fluoroquinolone antibiotics, such as LVFX, not only caused resistance in disease-causing microorganisms but also increased environmental pollution. Therefore, reduction of drug dosage is of general interest.
尽管有许多关于树枝状大分子在生物医学应用方面的研究，但阴离子磷树枝状大分子的抗菌活性尚未得到探索。在我们的研究中，我们评估了修饰后的阳离子和阴离子树枝状大分子与左氧氟沙星（LVFX）联合应用对革兰氏阴性（ATCC 25922、ATCC 15442）和革兰氏阳性（ATCC 6538）细菌的抗菌活性。对于革兰氏阴性细菌，我们得出结论，由于协同作用，树枝状大分子和抗生素的组合产生了令人满意的结果。氟喹诺酮类抗生素（如 LVFX）的使用不仅导致致病微生物产生耐药性，而且增加了环境污染。因此，减少药物剂量是普遍关注的问题。
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