经颅磁刺激能否安全影响健康年轻成年人的听觉听阈？
Can theta burst stimulation safely influence auditory hearing thresholds in healthy young adults?
机构信息
CICS-Health Sciences Research Centre, University of Beira Interior, Covilhã 6200-506, Portugal; Dr. Lopes Dias School of Health - Polytechnic Institute of Castelo Branco, 6000-767, Portugal.
CICS-Health Sciences Research Centre, University of Beira Interior, Covilhã 6200-506, Portugal.
出版信息
Clin Neurophysiol. 2019 Oct;130(10):1900-1907. doi: 10.1016/j.clinph.2019.07.019. Epub 2019 Jul 29.
OBJECTIVE
This TBS sham-controlled study aimed to evaluate the effects of intermittent TBS (iTBS) and continuous TBS (cTBS) upon ipsilateral hearing thresholds after stimulation on the left auditory cortex.
METHODS
Sixty healthy adults, aged between 19 and 32 years (median of 23 years), were randomly distributed into three groups and underwent iTBS, cTBS or sham stimulation. Each double-blind experimental session comprised two pure tone audiometric evaluations per subject, before and after stimulation. To assess volunteer safety, a follow-up of at least 48 hours was implemented.
RESULTS
The iTBS group mean thresholds displayed a tendency to decrease after stimulation, predominantly in the 500 Hz-6000 Hz interval and group comparisons revealed significant differences between the iTBS and sham groups for 500 Hz (p = 0.041) and between the iTBS and cTBS groups for 4000 Hz (p = 0.038). Neither relevant side effects nor any significant hearing threshold impairment after active or sham stimulation were found.
CONCLUSIONS
A single stimulation session led to an effective neuromodulation of the auditory cortex, reflected in lower thresholds when using iTBS.
SIGNIFICANCE
These encouraging results with this safe noninvasive tool suggest that iTBS may have the potential to positively influence hearing thresholds.
目的
本经颅磁刺激（TBS）假刺激对照研究旨在评估左听觉皮层刺激后，间歇性 TBS（iTBS）和连续 TBS（cTBS）对同侧听力阈值的影响。
方法
60 名年龄在 19 至 32 岁之间（中位数 23 岁）的健康成年人被随机分为三组，分别接受 iTBS、cTBS 或假刺激。每个双盲实验疗程包括每个受试者两次纯音测听评估，在刺激前后进行。为了评估志愿者的安全性，实施了至少 48 小时的随访。
结果
iTBS 组的平均阈值在刺激后呈现出下降的趋势，主要在 500Hz-6000Hz 区间，组间比较显示 iTBS 组与假刺激组在 500Hz（p=0.041）和 iTBS 组与 cTBS 组在 4000Hz（p=0.038）之间存在显著差异。无论是在活跃刺激还是假刺激后，都没有发现相关的副作用或显著的听力阈值损伤。
结论
单次刺激导致听觉皮层的有效神经调节，iTBS 组的阈值更低。
意义
这种安全无创工具的令人鼓舞的结果表明，iTBS 可能具有积极影响听力阈值的潜力。
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