血管加压素与去甲肾上腺素在大鼠蓝斑中共存：热损伤和神经毒性损伤后其在远隔脑区水平的差异性降低

Vasopressin and noradrenaline coexistence in the rat locus ceruleus: differential decreases of their levels in distant brain areas after thermal and neurotoxic lesions.

作者信息

Caffé A R, van Leeuwen F W, Buijs R M, van der Gugten J

机构信息

Netherlands Institute for Brain Research, Amsterdam.

出版信息

Brain Res. 1988 Sep 6;459(2):386-90. doi: 10.1016/0006-8993(88)90657-9.

DOI:10.1016/0006-8993(88)90657-9

PMID:3140998

Abstract

Vasopressin (VP) and noradrenaline (NA) coexist in the rat locus ceruleus (LC). After thermal lesions of LC, however, no detectable loss of VP-immunoreactive fibers was examined in the brain. VP and NA levels were also measured in the cortex, hippocampus and cerebellum, after unilateral LC lesions. Only significant ipsilateral depletions of NA levels were found. Therefore, no indications were obtained for VP transport by LC neurons towards distant brain areas.

摘要

血管加压素（VP）和去甲肾上腺素（NA）共存于大鼠蓝斑（LC）中。然而，在对LC进行热损伤后，并未检测到大脑中VP免疫反应性纤维有明显损失。在单侧LC损伤后，还对皮质、海马体和小脑中的VP和NA水平进行了测量。仅发现NA水平在同侧有显著降低。因此，未获得LC神经元向远处脑区转运VP的迹象。