比较 Behcet 病患者和健康对照者的光学相干断层扫描血管造影结果。
Comparison of Optical Coherence Tomography Angiography Findings in Patients with Behçet's Disease and Healthy Controls.
机构信息
Ophthalmologist, Department of Ophthalmology, Denizli State Hospital , Denizli, Turkey.
Dermatologist, Department of Dermatology, Ankara Numune Training and Research Hospital , Ankara, Turkey.
出版信息
Ocul Immunol Inflamm. 2020 Jul 3;28(5):806-813. doi: 10.1080/09273948.2019.1635167. Epub 2019 Aug 15.
PURPOSE
To investigate optical coherence tomography angiography (OCTA) findings in patients with Behçet's disease (BD).
METHODS
Ninety-four eyes of 49 patients with BD and 53 eyes of 53 healthy subjects were included. Vascular density (VD), foveal avascular zone (FAZ) area, perifoveal capillary hypoperfusion, perifoveal capillary network disorganization, and FAZ irregularity were analyzed.
RESULTS
OCTA revealed retinal VD reduction and higher perifoveal capillary hypoperfusion, perifoveal capillary network disorganization and FAZ irregularity in ocular Behçet's compared to nonocular Behçet's ( = .000). However, compared to normal eyes, there was no difference between any OCTA measurements in nonocular BD patients. The mean area of FAZ was not different in any group ( = .266). In ocular Behçet, visual acuity was inversely correlated with FAZ area and FAZ irregularity.
CONCLUSION
Retinal VD decreases and perifoveal microvascular network changes in ocular Behçet's. FAZ irregularity may be a more valuable marker than FAZ area for indicating ocular involvement.
目的
研究 Behçet 病（BD）患者的光相干断层扫描血管造影（OCTA）结果。
方法
纳入 49 例 BD 患者的 94 只眼和 53 例健康对照者的 53 只眼。分析血管密度（VD）、中心凹无血管区（FAZ）面积、旁中心毛细血管灌注不足、旁中心毛细血管网紊乱和 FAZ 不规则。
结果
OCTA 显示，与非眼部 Behçet 相比，眼部 Behçet 患者视网膜 VD 降低，旁中心毛细血管灌注不足、旁中心毛细血管网紊乱和 FAZ 不规则更为明显（=.000）。然而，与正常眼相比，非眼部 BD 患者的任何 OCTA 测量值之间均无差异。各组 FAZ 平均面积无差异（=.266）。在眼部 Behçet 中，视力与 FAZ 面积和 FAZ 不规则呈负相关。
结论
眼部 Behçet 患者视网膜 VD 降低，旁中心微血管网络改变。FAZ 不规则可能比 FAZ 面积更能作为提示眼部受累的指标。
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