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青少年黄色肉芽肿的细胞学诊断:一种罕见的组织细胞疾病。

Cytological diagnosis of juvenile xanthogranuloma: A rare histiocytic disorder.

作者信息

Chauhan Shivangi, Diwaker Preeti, Singh Aakanksha, Gogoi Priyanka, Arora Vinod K

机构信息

Department of Pathology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.

出版信息

Diagn Cytopathol. 2020 Jan;48(1):66-70. doi: 10.1002/dc.24310. Epub 2019 Aug 20.

Abstract

Juvenile xanthogranuloma (JXG) is a rare type of non-Langerhan cell histiocytic disorder, which is mostly confined to skin of head and neck. It is a self-limiting benign condition, which does not require surgery. We present a case of 8-month-old girl child with multiple yellowish brown colored papules over scalp, face, and neck. A clinical diagnosis of cutaneous mastocytosis was made. Fine-needle aspiration cytology (FNAC) smears showed foamy macrophages along with mixed inflammatory infiltrate and few touton giant cells. A diagnosis of JXG was rendered which was confirmed on histopathology and immunohistochemistry.Juvenile xanthogranuloma can be diagnosed on FNAC based on its characteristic cytologic features; however, it requires a high index of suspicion by cytopathologist. Cytological diagnosis of JXG can save the patient from unnecessary surgical biopsy or excision.

摘要

幼年黄色肉芽肿(JXG)是一种罕见的非朗格汉斯细胞组织细胞增多症,主要局限于头颈部皮肤。它是一种自限性良性疾病,无需手术治疗。我们报告一例8个月大女童,头皮、面部和颈部有多个黄棕色丘疹。临床诊断为皮肤肥大细胞增多症。细针穿刺抽吸细胞学检查(FNAC)涂片显示有泡沫状巨噬细胞、混合性炎性浸润及少量图顿巨细胞。诊断为JXG,经组织病理学和免疫组织化学检查得以证实。幼年黄色肉芽肿可根据其特征性细胞学表现通过FNAC诊断;然而,这需要细胞病理学家有高度的怀疑指数。JXG的细胞学诊断可使患者避免不必要的手术活检或切除。

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