一段 50 年历史的技术推动了真核转录调控的发现。
A 50 year history of technologies that drove discovery in eukaryotic transcription regulation.
机构信息
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.
出版信息
Nat Struct Mol Biol. 2019 Sep;26(9):777-782. doi: 10.1038/s41594-019-0288-9. Epub 2019 Aug 22.
Abstract
Transcription regulation is critical to organism development and homeostasis. Control of expression of the 20,000 genes in human cells requires many hundreds of proteins acting through sophisticated multistep mechanisms. In this Historical Perspective, I highlight the progress that has been made in elucidating eukaryotic transcriptional mechanisms through an array of disciplines and approaches, and how this concerted effort has been driven by the development of new technologies.
摘要
转录调控对于生物体的发育和内稳态至关重要。人类细胞中 20000 个基因的表达控制需要数百种蛋白质通过复杂的多步骤机制来实现。在这篇历史观点中，我强调了通过一系列学科和方法阐明真核转录机制所取得的进展，以及新技术的发展如何推动了这一协同努力。
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