持久性有机污染物与多囊卵巢综合征之间的关联：一项系统评价和荟萃分析方案
Association between the persistent organic pollutants and polycystic ovary syndrome: A protocol for a systematic review and meta-analysis.
作者信息
Li Yan, Zhang Mei-Wei, Wang Ying-Ji
机构信息
First Affiliated Hospital, Heilongjiang University of Chinese Medicine.
College of Pharmacy, Harbin Medical University, Harbin, China.
出版信息
Medicine (Baltimore). 2019 Aug;98(34):e16948. doi: 10.1097/MD.0000000000016948.
BACKGROUND
Current evidence concerning the association between persistent organic pollutants (POPs) and polycystic ovary syndrome (PCOS) is inconsistent. The aim of the present systematic review and meta-analysis is to evaluate the role of POPs in PCOS.
METHODS
Databases including PubMed, Embase, Web of Science, and CNKI will be searched to identify qualified studies. All qualified studies regarding the association between POPs and PCOS will be included. The primary outcome of the present study is POPs levels in serum of subjects. Pooled analysis with corresponding 95% confidence intervals will be performed.
RESULTS
The comprehensive analysis and quantitative assessment will provide a better understanding of POPs concentrations in patients with PCOS.
CONCLUSION
This meta-analysis and systematic review will generate evidence of the association between POPs and PCOS.
PROSPERO REGISTRATION NUMBER
PROSPERO CRD42019126373.
背景
目前关于持久性有机污染物（POPs）与多囊卵巢综合征（PCOS）之间关联的证据并不一致。本系统评价和荟萃分析的目的是评估POPs在PCOS中的作用。
方法
将检索包括PubMed、Embase、Web of Science和CNKI在内的数据库，以识别合格的研究。将纳入所有关于POPs与PCOS之间关联的合格研究。本研究的主要结局是受试者血清中POPs水平。将进行相应95%置信区间的合并分析。
结果
综合分析和定量评估将有助于更好地了解PCOS患者体内POPs的浓度。
结论
这项荟萃分析和系统评价将得出POPs与PCOS之间关联的证据。
PROSPERO注册号：PROSPERO CRD42019126373。
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