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肥胖症患者接受减肥手术的效果。

Outcomes of bariatric surgery in patients with depression disorders.

机构信息

Department of General Surgery, Assuta Medical Center, Tel-Aviv, Israel.

Department of Nutrition, Assuta Medical Center, Tel-Aviv, Israel.

出版信息

PLoS One. 2019 Aug 27;14(8):e0221576. doi: 10.1371/journal.pone.0221576. eCollection 2019.

Abstract

OBJECTIVE

To determine the impact of sleeve gastrectomy in patients suffering from depression compared with those who are not in a depressive state.

INTRODUCTION

Obesity is considered a global epidemic. Often patients with obesity suffer from depressive state. Depressive disorders may be both a cause and a consequence of obesity.

MATERIAL AND METHODS

The study includes 300 consecutives patients that underwent laparoscopic sleeve gastrectomy. Out of the 300 patients, 253 (84.33%) of them completed the follow up for three years.

RESULTS

Out of the 300-patients, with the average age of 41.65±11.05 years old, the ratio of males to females was 1:2. The average baseline BMI was 42.02 kg/m2. A total of 105 (35.33%) of the patients suffer from depression, which was more common in male (43%) than in female (31.5%), with statistically significant difference (p = .05). Comparing the weight loss after surgery in both groups, the mean weight loss in the depression-group was 12.0 ΔBMI and in the non-depression group was 13.03 ΔBMI, (p< .001). After three years, 94 (88.68%) patients of the depression group responded as they were optimistic and satisfied with the results of the operation, with positive changes in their lives, 8 (7.55%) did not experience change and 4 (3.77%) expressed to have worsened their depressive state.

CONCLUSION

Laparoscopic sleeve gastrectomy is successful and leads to weight loss even in subjects who are affected by depression syndrome.

摘要

目的

比较患有抑郁症和非抑郁状态的患者行袖状胃切除术的效果。

简介

肥胖症被认为是一种全球性的流行疾病。通常,肥胖症患者会伴有抑郁状态。抑郁障碍可能既是肥胖的原因,也是肥胖的结果。

材料和方法

本研究纳入了 300 例连续接受腹腔镜袖状胃切除术的患者。在这 300 例患者中,有 253 例(84.33%)完成了 3 年的随访。

结果

在这 300 例患者中,平均年龄为 41.65±11.05 岁,男女比例为 1:2。平均基线 BMI 为 42.02kg/m2。共有 105 例(35.33%)患者患有抑郁症,其中男性(43%)比女性(31.5%)更为常见,差异有统计学意义(p=0.05)。比较两组患者术后的体重减轻情况,抑郁组的平均体重减轻量为 12.0ΔBMI,非抑郁组为 13.03ΔBMI,差异有统计学意义(p<0.001)。3 年后,抑郁组 94 例(88.68%)患者对手术结果表示乐观和满意,生活发生积极变化,8 例(7.55%)无变化,4 例(3.77%)表示抑郁状态恶化。

结论

腹腔镜袖状胃切除术是成功的,即使在患有抑郁综合征的患者中也能导致体重减轻。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd64/6711535/2a97f401e9a4/pone.0221576.g001.jpg

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