连续流动条件下碱催化硝基烷烃与对苯醌甲基化物的1,6-共轭加成反应
Base-Catalyzed 1,6-Conjugate Addition of Nitroalkanes to -Quinone Methides under Continuous Flow.
作者信息
Pandey Rajat, Anand Ramasamy Vijaya
机构信息
Indian Institute of Science Education and Research (IISER) Mohali, Sector 81, Manauli (PO), S. A. S. Nagar, Punjab 140306, India.
出版信息
ACS Omega. 2018 Oct 24;3(10):13967-13976. doi: 10.1021/acsomega.8b01971. eCollection 2018 Oct 31.
Abstract
A mild base-catalyzed protocol for the synthesis of substituted nitroalkane derivatives has been developed under continuous flow using a microreaction technique. This transformation basically involves the 1,6-conjugate addition of nitroalkanes to -quinone methides, leading to the substituted nitroalkanes in good to excellent yields.
摘要
已经开发出一种温和的碱催化方案，用于在连续流动条件下使用微反应技术合成取代的硝基烷衍生物。这种转化基本上涉及硝基烷对醌甲基化物的1,6-共轭加成，从而以良好至优异的产率得到取代的硝基烷。
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