Hypertension and Cardiovascular Prevention Unit, Diagnosis and Therapeutic Center, Paris-Descartes University, Hôtel-Dieu Hospital, AP-HP, Paris.
Santé Publique France, The French Public Health Agency, Saint-Maurice, France.
J Hypertens. 2020 Feb;38(2):249-256. doi: 10.1097/HJH.0000000000002228.
Increased aortic stiffness could be one of the mechanisms by which obesity increases cardiovascular risk independently of traditional risk factors. Studies have suggested that anthropometric indices may be predictors of cardiovascular risk but few studies have investigated their relations with aortic stiffness in high cardiovascular risk population. We investigated the strength of correlation between different anthropometric indices with aortic stiffness in hypertensive and diabetic patients.
A cross-sectional study was performed in 474 hypertensive patients. Anthropometric indices were calculated: BMI, waist circumference, waist-hip ratio, and waist-height ratio (WHtR). Aortic stiffness was assessed by measurement of carotid-femoral pulse wave velocity (PWV). Correlations between indices and PWV were investigated by linear regression analyses and hierarchical analyses after adjusting for cardiovascular risk factors.
Regional anthropometric indices were more strongly correlated with PWV than BMI in both sexes. In linear regression analyses, WHtR presented the highest correlation with PWV than other indices in our study population. In adjusted hierarchical regression used, WHtR had the highest additive value on top of BMI while there no additive value of BMI on top of WHtR. These differences remained after adjustment on cardiovascular events. In men WHtR was more closely correlated with PWV than others. In women, waist-hip ratio and WHtR were equally correlated with PWV compared with BMI.
Regional anthropometric indices are more closely correlated with PWV than BMI in hypertensive patients. WHtR presents the highest correlation with PWV beyond BMI.
The study was registered in the French National Agency for Medicines and Health Products Safety (No. 2013-A00227-38) and was approved by the Advisory Committee for Protection of Persons in Biomedical Research.
肥胖症可通过增加主动脉僵硬度增加心血管风险，而与传统风险因素无关。研究表明，人体测量指数可能是心血管风险的预测指标，但很少有研究调查它们与高心血管风险人群主动脉僵硬度的关系。我们研究了不同人体测量指数与高血压和糖尿病患者主动脉僵硬度之间的相关性。
在 474 例高血压患者中进行了横断面研究。计算了人体测量指数：体重指数（BMI）、腰围、腰臀比和腰围身高比（WHtR）。通过测量颈动脉-股动脉脉搏波速度（PWV）评估主动脉僵硬度。通过线性回归分析和分层分析，在调整心血管危险因素后，研究了指数与 PWV 之间的相关性。
在男性和女性中，区域人体测量指数与 PWV 的相关性均强于 BMI。在线性回归分析中，WHtR 与 PWV 的相关性在本研究人群中高于其他指数。在使用调整后的分层回归中，WHtR 在 BMI 之上具有最高的附加价值，而 BMI 在 WHtR 之上没有附加价值。这些差异在调整心血管事件后仍然存在。在男性中，WHtR 与 PWV 的相关性强于其他指数。在女性中，与 BMI 相比，腰臀比和 WHtR 与 PWV 的相关性相当。
在高血压患者中，区域人体测量指数与 PWV 的相关性强于 BMI。WHtR 在 BMI 之外与 PWV 的相关性最高。
该研究在法国国家药品和保健产品安全局（编号 2013-A00227-38）注册，并获得了生物医学研究保护人员咨询委员会的批准。
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