Godoy-Vitorino Filipa
Department of Microbiology and Medical Zoology, University of Puerto Rico School of Medicine, Medical Sciences Campus, San Juan, PR, USA.
Ann Transl Med. 2019 Jul;7(14):342. doi: 10.21037/atm.2019.06.56.
The first life forms on earth were Prokaryotic, and the evolution of all Eukaryotic life occurred with the help of bacteria. Animal-associated microbiota also includes members of the archaea, fungi, protists, and viruses. The genomes of this host-associated microbial life are called the microbiome. Across the mammalian tree, microbiomes guarantee the development of immunity, physiology, and resistance to pathogens. In humans, all surfaces and cavities are colonized by a microbiome, maintained by a careful balance between the host response and its colonizers-thus humans are considered now supraorganisms. These microbiomes supply essential ecosystem services that benefit health through homeostasis, and the loss of the indigenous microbiota leads to dysbiosis, which can have significant consequences to disease. This educational review aims to describe the importance of human microbial ecology, explain the ecological terms applied to the study of the human microbiome, developments within the cutting-edge microbiome field, and implications to diagnostic and treatment.
地球上最早的生命形式是原核生物,所有真核生物的进化都是在细菌的帮助下发生的。与动物相关的微生物群还包括古细菌、真菌、原生生物和病毒的成员。这种与宿主相关的微生物生命的基因组被称为微生物组。在整个哺乳动物谱系中,微生物组保证了免疫、生理功能以及对病原体的抵抗力的发展。在人类中,所有表面和腔道都被微生物组定殖,其通过宿主反应与其定殖者之间的精确平衡得以维持——因此人类现在被视为超生物体。这些微生物组提供基本的生态系统服务,通过体内平衡促进健康,而原生微生物群的丧失会导致生态失调,这可能对疾病产生重大影响。这篇教育综述旨在描述人类微生物生态学的重要性,解释应用于人类微生物组研究的生态学术语、前沿微生物组领域的进展以及对诊断和治疗的影响。