地中海饮食可提高 IVF 胚胎产量：一项前瞻性队列研究。
Mediterranean diet improves embryo yield in IVF: a prospective cohort study.
机构信息
Department of Reproductive Center, Peking University Shenzhen Hospital, No. 1120 Lianhua Road, Shenzhen, Guangdong, 518036, People's Republic of China.
出版信息
Reprod Biol Endocrinol. 2019 Sep 2;17(1):73. doi: 10.1186/s12958-019-0520-9.
BACKGROUND
Mediterranean diet (MediDiet) had been reported to be beneficial to human health. However the relationship between diet pattern and outcomes of in vitro fertilization (IVF) treatment was scarcely researched. This study was aimed to explore the correlation between MediDiet pattern of infertile women and their clinical outcomes of IVF cycles.
METHODS
An observational prospective cohort study was conducted in the reproductive center from September 2016 to December 2017. Seven hundred infertile women about to undergo IVF treatment were asked to conduct a questionnaire survey. Patients were assigned to higher MediDiet adherence group or lower MediDiet adherence group according to their Mediterranean diet scores. Laboratory parameters and clinical outcomes were compared and those were different between groups were further analyzed for their relationship with MediDiet adherence.
RESULTS
A total of 590 women were finally included in the study. According to MediDiet scores, 228 participants were categorized as higher MediDiet adherence group and 362 others as lower MediDiet adherence group. No significant differences were found in baseline characteristics between groups. Higher MediDiet adherence group showed larger number of embryos available (8.40 ± 5.26 vs 7.40 ± 4.71, P = 0.028). Clinical pregnancy rate and implantation rate were similar between the two groups. In further correlation tests and multivariate linear regression analysis, number of fertilized oocytes and embryo yield were positively correlated to MediDiet adherence of participants.
CONCLUSION
Infertile women with greater adherence to Mediterranean diet pattern were likely to obtain more embryos available in IVF cycle.
背景
地中海饮食（MediDiet）已被报道对人类健康有益。然而，饮食模式与体外受精（IVF）治疗结果之间的关系尚未得到充分研究。本研究旨在探讨不孕妇女 MediDiet 模式与 IVF 周期临床结局之间的相关性。
方法
本研究采用观察性前瞻性队列研究，于 2016 年 9 月至 2017 年 12 月在生殖中心进行。700 名即将接受 IVF 治疗的不孕妇女被要求进行问卷调查。根据地中海饮食评分，将患者分为高 MediDiet 依从组或低 MediDiet 依从组。比较两组的实验室参数和临床结局，并对组间差异进行分析，以探讨其与 MediDiet 依从性的关系。
结果
共有 590 名妇女最终纳入研究。根据 MediDiet 评分，228 名参与者被归类为高 MediDiet 依从组，362 名参与者被归类为低 MediDiet 依从组。两组间基线特征无显著差异。高 MediDiet 依从组可获得的胚胎数量更多（8.40±5.26 比 7.40±4.71，P=0.028）。两组间临床妊娠率和种植率相似。进一步的相关测试和多元线性回归分析显示，受精卵数和胚胎产量与参与者的 MediDiet 依从性呈正相关。
结论
遵循地中海饮食模式的不孕妇女在 IVF 周期中可能获得更多可用胚胎。
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