RNA 乙酰转移酶 Kre33/NAT10 的结构与功能的最新进展
Recent Advances on the Structure and Function of RNA Acetyltransferase Kre33/NAT10.
机构信息
Département des Sciences Biologiques and Centre d'Excellence en Recherche sur les Maladies Orphelines-Fondation Courtois (CERMO-FC), Université du Québec à Montréal, Montréal, QC H3C 3P8, Canada.
出版信息
Cells. 2019 Sep 5;8(9):1035. doi: 10.3390/cells8091035.
Ribosome biogenesis is one of the most energy demanding processes in the cell. In eukaryotes, the main steps of this process occur in the nucleolus and include pre-ribosomal RNA (pre-rRNA) processing, post-transcriptional modifications, and assembly of many non-ribosomal factors and ribosomal proteins in order to form mature and functional ribosomes. In yeast and humans, the nucleolar RNA acetyltransferase Kre33/NAT10 participates in different maturation events, such as acetylation and processing of 18S rRNA, and assembly of the 40S ribosomal subunit. Here, we review the structural and functional features of Kre33/NAT10 RNA acetyltransferase, and we underscore the importance of this enzyme in ribosome biogenesis, as well as in acetylation of non-ribosomal targets. We also report on the role of human NAT10 in Hutchinson-Gilford progeria syndrome.
核糖体生物发生是细胞中最耗能的过程之一。在真核生物中，该过程的主要步骤发生在核仁中，包括前核糖体 RNA（pre-rRNA）加工、转录后修饰以及许多非核糖体因子和核糖体蛋白的组装，以形成成熟和功能的核糖体。在酵母和人类中，核仁 RNA 乙酰转移酶 Kre33/NAT10 参与不同的成熟事件，如 18S rRNA 的乙酰化和加工，以及 40S 核糖体亚基的组装。在这里，我们回顾了 Kre33/NAT10 RNA 乙酰转移酶的结构和功能特征，并强调了该酶在核糖体生物发生以及非核糖体靶标的乙酰化中的重要性。我们还报告了人类 NAT10 在亨廷顿病中的作用。
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