Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Cells. 2019 Sep 5;8(9):1036. doi: 10.3390/cells8091036.
The mechanotransduction is the process by which cells sense mechanical stimuli such as elasticity, viscosity, and nanotopography of extracellular matrix and translate them into biochemical signals. The mechanotransduction regulates several aspects of the cell behavior, including migration, proliferation, and differentiation in a time-dependent manner. Several reports have indicated that cell behavior and fate are not transmitted by a single signal, but rather by an intricate network of many signals operating on different length and timescales that determine cell fate. Since cell biology and biomaterial technology are fundamentals in cell-based regenerative therapies, comprehending the interaction between cells and biomaterials may allow the design of new biomaterials for clinical therapeutic applications in tissue regeneration. In this work, we present the most relevant mechanism by which the biomechanical properties of extracellular matrix (ECM) influence cell reprogramming, with particular attention on the new technologies and materials engineering, in which are taken into account not only the biochemical and biophysical signals patterns but also the factor time.
力学转导是细胞感知细胞外基质的弹性、粘性和纳米形貌等机械刺激并将其转化为生化信号的过程。力学转导以时间依赖的方式调节细胞行为的多个方面，包括迁移、增殖和分化。有几项报告表明，细胞行为和命运不是由单个信号传递的，而是由许多信号在不同的长度和时间尺度上的复杂网络传递的，这些信号决定了细胞的命运。由于细胞生物学和生物材料技术是基于细胞的再生治疗的基础，因此了解细胞与生物材料之间的相互作用可以设计用于组织再生的临床治疗应用的新型生物材料。在这项工作中，我们介绍了细胞外基质（ECM）的生物力学特性影响细胞重编程的最相关机制，特别关注新技术和材料工程，其中不仅考虑了生化和生物物理信号模式，还考虑了时间因素。
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