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成人脊柱畸形矫正分期手术与同日手术的短期疗效

Short-Term Outcomes of Staged Versus Same-Day Surgery for Adult Spinal Deformity Correction.

作者信息

Arzeno Alexander H, Koltsov Jayme, Alamin Todd F, Cheng Ivan, Wood Kirkham B, Hu Serena S

机构信息

Department of Orthopaedic Surgery, Stanford University School of Medicine, 450 Broadway St, Pavillion A FL 1 MC6110, Redwood City, CA, 94063, USA.

Department of Orthopaedic Surgery, Stanford University School of Medicine, 450 Broadway St, Pavillion A FL 1 MC6110, Redwood City, CA, 94063, USA.

出版信息

Spine Deform. 2019 Sep;7(5):796-803.e1. doi: 10.1016/j.jspd.2018.12.008.

Abstract

STUDY DESIGN

Retrospective cohort study.

OBJECTIVES

Assess differences between staged (≤3 days) and same-day surgery in perioperative factors, radiographic measures, and complications.

SUMMARY OF BACKGROUND DATA

Surgical adult spinal deformity correction may require combined anterior and posterior approaches. To modulate risk, some surgeons perform surgery that is expected to be longer and/or more complex in two stages. Prior studies comparing staged (≥7 days) and same-day surgery demonstrated mixed results and none have examined results with shorter staging intervals.

METHODS

Retrospective review of adults undergoing combined anterior/posterior approaches for spinal deformity over a 3-year period at a single institution (n=92). Univariate differences between staged and same-day surgery were assessed with chi-squared, Fisher exact, and Mann-Whitney U tests. Generalized estimating equations assessed whether differences in perioperative outcomes between groups remained after adjusting for differences in demographic and surgical characteristics.

RESULTS

In univariate analyses, staged surgery was associated with a length of stay (LOS) 3 days longer than same-day surgery (9.2 vs. 6.3 days, p < .001), and greater operative time, blood loss, transfusion requirement, and days in intensive care unit (p < .001 for each). Staged surgery had a higher rate of thrombotic events (p = .011) but did not differ in readmission rates or other complications. Radiographically, improvements in Cobb angle (average 13° vs. 17°, p = .028), lumbar lordosis (average 14° vs. 23°, p = .019), and PI-LL mismatch (average 10° vs. 2° p = .018) were greater for staged surgery, likely related to more extensive use of osteotomies in the staged group. After risk adjustment, taking into account the procedural specifics including longer fusion constructs and greater number of osteotomies, LOS no longer differed between staged and same-day surgery; however, the total operative time was 98 minutes longer for staged surgery (p < .001). Differences in blood loss between groups was accounted for by differences in operative time and patient and surgical characteristics.

CONCLUSIONS

Although univariate analysis of our results were in accordance with previously published works, multivariate analysis allowing individual case risk adjustment revealed that LOS was not significantly increased in the staged group as reported in previous studies. There was no difference in infection rates as previously described but an increase in thrombotic events was observed.

LEVEL OF EVIDENCE

Level III.

摘要

研究设计

回顾性队列研究。

目的

评估分期手术(≤3天)与同日手术在围手术期因素、影像学测量指标及并发症方面的差异。

背景数据总结

成人脊柱畸形矫正手术可能需要前后联合入路。为降低风险,一些外科医生分两期进行预计时间更长和/或更复杂的手术。既往比较分期手术(≥7天)与同日手术的研究结果不一,且尚无研究探讨较短分期间隔的手术结果。

方法

对某单一机构3年内接受前后联合入路脊柱畸形手术的成人患者进行回顾性分析(n = 92)。采用卡方检验、Fisher精确检验和Mann-Whitney U检验评估分期手术与同日手术的单因素差异。广义估计方程用于评估在调整人口统计学和手术特征差异后,两组围手术期结局的差异是否仍然存在。

结果

在单因素分析中,分期手术的住院时间(LOS)比同日手术长3天(9.2天 vs. 6.3天,p < .001),且手术时间、失血量、输血需求及重症监护病房天数均更多(每项p < .001)。分期手术的血栓形成事件发生率更高(p = .011),但再入院率及其他并发症无差异。影像学方面,分期手术的Cobb角改善(平均13° vs. 17°,p = .028)、腰椎前凸改善(平均14° vs. 23°,p = .019)及PI-LL失配改善(平均10° vs. 2°,p = .018)更大,这可能与分期手术组更广泛地使用截骨术有关。在进行风险调整后,考虑到手术细节,包括更长的融合节段和更多的截骨术,分期手术与同日手术的住院时间不再有差异;然而,分期手术总手术时间长98分钟(p < .001)。两组失血量的差异可由手术时间及患者和手术特征的差异来解释。

结论

尽管我们结果的单因素分析与既往发表的研究一致,但多因素分析进行个体病例风险调整后显示,分期手术组住院时间并未如既往研究报道的那样显著增加。感染率与既往描述无差异,但观察到血栓形成事件增加。

证据级别

III级。

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