CUT&RUNTools：用于 CUT&RUN 处理和足迹分析的灵活流水线。
CUT&RUNTools: a flexible pipeline for CUT&RUN processing and footprint analysis.
机构信息
Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard Chan School of Public Health, Boston, MA, USA.
Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
出版信息
Genome Biol. 2019 Sep 9;20(1):192. doi: 10.1186/s13059-019-1802-4.
We introduce CUT&RUNTools as a flexible, general pipeline for facilitating the identification of chromatin-associated protein binding and genomic footprinting analysis from antibody-targeted CUT&RUN primary cleavage data. CUT&RUNTools extracts endonuclease cut site information from sequences of short-read fragments and produces single-locus binding estimates, aggregate motif footprints, and informative visualizations to support the high-resolution mapping capability of CUT&RUN. CUT&RUNTools is available at https://bitbucket.org/qzhudfci/cutruntools/ .
我们介绍 CUT＆RUNTools，这是一个灵活的通用管道，用于从抗体靶向 CUT＆RUN 原始切割数据中促进染色质相关蛋白结合和基因组足迹分析的鉴定。CUT＆RUNTools 从短读片段的序列中提取内切酶切割位点信息，并生成单基因座结合估计值、聚合基序足迹和信息丰富的可视化效果，以支持 CUT＆RUN 的高分辨率映射能力。CUT＆RUNTools 可在 https://bitbucket.org/qzhudfci/cutruntools/ 获得。
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