Department of Internal Medicine, New York University Langone Health, New York City, NY, USA.
Rutgers New Jersey Medical School, Newark, NJ, USA.
Int J Clin Pract. 2020 Jan;74(1):e13416. doi: 10.1111/ijcp.13416. Epub 2019 Oct 23.
Osteoarthritis is a common debilitating condition affecting a substantial portion of the population and is an accepted consequence of ageing and overuse. Whilst surgical interventions are a definitive approach, most cases are managed medically with analgesia. Pharmacological therapies have included acetaminophen, non-steroidal anti-inflammatory drugs and opiates. Although significant controversies exist in the use of opioids for chronic musculoskeletal pain, many leading guidelines continue to recommend its use despite increasing evidence to suggest an increase in addiction, morbidity and mortality. With the opiate crisis growing, we re-examine the role opiates have in this chronic condition and current data, and briefly evaluate alternative therapies.
骨关节炎是一种常见的使人虚弱的疾病,影响了相当一部分人群,并且被认为是衰老和过度使用的结果。虽然手术干预是一种明确的方法,但大多数病例都通过镇痛药物来进行医学治疗。药物治疗包括对乙酰氨基酚、非甾体抗炎药和阿片类药物。尽管在慢性肌肉骨骼疼痛中使用阿片类药物存在重大争议,但许多主要指南仍继续推荐使用阿片类药物,尽管越来越多的证据表明阿片类药物成瘾、发病率和死亡率增加。随着阿片类药物危机的加剧,我们重新审视了阿片类药物在这种慢性疾病中的作用和当前数据,并简要评估了替代疗法。