GPCR Drug Discovery: Emerging Targets, Novel Approaches and Future Trends.
作者信息
Zhou Jia, Wild Christopher
机构信息
Chemical Biology Program Department of Pharmacology and Toxicology University of Texas Medical Branch Galveston, TX 77555, United States.
Distinguished Faculty of Chemistry and Department Chair Department of Chemistry, Engineering, Geology, and Physics San Jacinto College Houston, TX 77089, United States.
出版信息
Curr Top Med Chem. 2019;19(16):1363-1364. doi: 10.2174/156802661916190828093500.
Abstract
摘要
相似文献
1
GPCR Drug Discovery: Emerging Targets, Novel Approaches and Future Trends.
Curr Top Med Chem. 2019;19(16):1363-1364. doi: 10.2174/156802661916190828093500.
2
Biasing GPCR signaling from inside.
Sci Signal. 2014 Jan 28;7(310):pe3. doi: 10.1126/scisignal.2005021.
3
Selective GPCR ligands.
Bioorg Med Chem. 2015 Jul 15;23(14):3879. doi: 10.1016/j.bmc.2015.03.030. Epub 2015 Mar 14.
4
GPCR profiling: from hits to leads and from genotype to phenotype.
Drug Discov Today Technol. 2015 Nov;18:30-7. doi: 10.1016/j.ddtec.2015.10.005. Epub 2015 Nov 6.
5
Tuning up the right signal: chemical and genetic approaches to study GPCR functions.
Curr Opin Cell Biol. 2014 Apr;27:51-5. doi: 10.1016/j.ceb.2013.11.006. Epub 2013 Dec 8.
6
GPCRomics: An Approach to Discover GPCR Drug Targets.
Trends Pharmacol Sci. 2019 Jun;40(6):378-387. doi: 10.1016/j.tips.2019.04.001. Epub 2019 May 8.
7
Emerging structural insights into biased GPCR signaling.
Trends Biochem Sci. 2014 Dec;39(12):594-602. doi: 10.1016/j.tibs.2014.10.001. Epub 2014 Nov 4.
8
cAMP assays in GPCR drug discovery.
Methods Cell Biol. 2017;142:51-57. doi: 10.1016/bs.mcb.2017.07.014. Epub 2017 Sep 23.
9
New winds in GPCR-based drug discovery.
Future Med Chem. 2016 Apr;8(6):605-8. doi: 10.4155/fmc-2016-0008.
10
Emerging Approaches to GPCR Ligand Screening for Drug Discovery.
Trends Mol Med. 2015 Nov;21(11):687-701. doi: 10.1016/j.molmed.2015.09.002. Epub 2015 Oct 16.
引用本文的文献
1
GPR52 regulates cAMP in T cells but is dispensable for encephalitogenic responses.
Front Immunol. 2023 Jan 24;13:1113348. doi: 10.3389/fimmu.2022.1113348. eCollection 2022.
2
Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia.
Front Cell Dev Biol. 2022 Sep 14;10:959239. doi: 10.3389/fcell.2022.959239. eCollection 2022.
3
Post-Translational Modifications of G Protein-Coupled Receptors Revealed by Proteomics and Structural Biology.
Front Chem. 2022 Mar 10;10:843502. doi: 10.3389/fchem.2022.843502. eCollection 2022.
4
Drug-Targeted Genomes: Mutability of Ion Channels and GPCRs.
Biomedicines. 2022 Mar 3;10(3):594. doi: 10.3390/biomedicines10030594.
5
Monobodies as tool biologics for accelerating target validation and druggable site discovery.
RSC Med Chem. 2021 Sep 13;12(11):1839-1853. doi: 10.1039/d1md00188d. eCollection 2021 Nov 17.
6
Discovery of Potent and Brain-Penetrant GPR52 Agonist that Suppresses Psychostimulant Behavior.
J Med Chem. 2020 Nov 25;63(22):13951-13972. doi: 10.1021/acs.jmedchem.0c01498. Epub 2020 Nov 16.
本文引用的文献
1
Advances in Dopamine D1 Receptor Ligands for Neurotherapeutics.
Curr Top Med Chem. 2019;19(16):1365-1380. doi: 10.2174/1568026619666190712210903.
2
GPCRs and Insulin Receptor Signaling in Conversation: Novel Avenues for Drug Discovery.
Curr Top Med Chem. 2019;19(16):1436-1444. doi: 10.2174/1568026619666190712211642.
3
Targeting the 5-HT2C Receptor in Biological Context and the Current State of 5-HT2C Receptor Ligand Development.
Curr Top Med Chem. 2019;19(16):1381-1398. doi: 10.2174/1568026619666190709101449.
4
Overcoming the Psychiatric Side Effects of the Cannabinoid CB1 Receptor Antagonists: Current Approaches for Therapeutics Development.
Curr Top Med Chem. 2019;19(16):1418-1435. doi: 10.2174/1568026619666190708164841.
5
Targeting the PAC1 Receptor for Neurological and Metabolic Disorders.
Curr Top Med Chem. 2019;19(16):1399-1417. doi: 10.2174/1568026619666190709092647.
6
PET Imaging of Adenosine Receptors in Diseases.
Curr Top Med Chem. 2019;19(16):1445-1463. doi: 10.2174/1568026619666190708163407.
7
Recent Advances of Small Molecular Regulators Targeting G Protein- Coupled Receptors Family for Oncology Immunotherapy.
Curr Top Med Chem. 2019;19(16):1464-1483. doi: 10.2174/1568026619666190628115644.
Zotero 插件