miR-200 家族在神经退行性疾病中的调控作用。
Regulatory roles of the miR-200 family in neurodegenerative diseases.
机构信息
Department of Neurology, The Affiliated Hospital of Southwest Medical University, Taiping Street, Jiangyang District, Luzhou, 646000, China; Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Taiping Street, Jiangyang District, Luzhou, 646000, China.
出版信息
Biomed Pharmacother. 2019 Nov;119:109409. doi: 10.1016/j.biopha.2019.109409. Epub 2019 Sep 10.
Neurodegenerative diseases are chronic and progressive disorders which are not effectively treated through adopting conventional therapies. For this unmet medical need, alternative therapeutic methods including gene-based therapies are emphasized. MicroRNAs (miRNAs) are small non-coding RNAs which can regulate gene expression at the post-transcriptional level. In recent years, dysregulated miRNAs have been indicated to be implicated in the occurrence and development of neurodegenerative diseases. They are investigated as candidates for diagnostic and prognostic biomarkers, as well as therapeutic targets. The miR-200 family consists of miR-200a, -200b, -200c, -141, and -429. Numerous studies have found that miR-200 family members are associated with the pathogenesis of neurodegenerative diseases. It is reported that miR-200 family members are aberrantly expressed in several neurodegenerative diseases, participating in various cellular processes including beta-amyloid (Aβ) secretion, alpha-synuclein aggregation and DNA repair, etc. In the present review, we summarize the recent progress in the roles of miR-200 family in neurodegenerative diseases.
神经退行性疾病是慢性且进行性的疾病，采用常规疗法无法有效治疗。针对这一未满足的医疗需求，包括基于基因的治疗方法在内的替代治疗方法受到了重视。microRNAs（miRNAs）是一种小型非编码 RNA，可以在转录后水平调控基因表达。近年来，失调的 miRNAs 被认为与神经退行性疾病的发生和发展有关。它们被作为诊断和预后生物标志物以及治疗靶点进行研究。miR-200 家族由 miR-200a、-200b、-200c、-141 和 -429 组成。大量研究发现，miR-200 家族成员与神经退行性疾病的发病机制有关。据报道，miR-200 家族成员在几种神经退行性疾病中表达异常，参与包括β-淀粉样蛋白（Aβ）分泌、α-突触核蛋白聚集和 DNA 修复等多种细胞过程。本综述总结了 miR-200 家族在神经退行性疾病中的作用的最新进展。
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