儿童慢性自发性荨麻疹与自身免疫性疾病的相关性研究。
Investigation of Autoimmune Disease in Children with Chronic Spontaneous Urticaria.
机构信息
Department of Pediatrics, University Hospital of Ioannina, Ioannina, Greece.
Child Health Department, Medical School, University of Ioannina, Ioannina, Greece.
出版信息
Int Arch Allergy Immunol. 2019;180(4):250-254. doi: 10.1159/000502521. Epub 2019 Sep 13.
INTRODUCTION
Chronic spontaneous urticaria (CSU) in childhood affects the quality of life of the patient and may be associated with other autoimmune diseases. The aim of this study was to investigate the association of autoimmune diseases with CSU in children.
METHODS
In a 3-year period, from 2015 to 2018, forty-nine children were diagnosed with CSU and monitored in the Outpatient Pediatric Allergy Clinic of the University Hospital of Ioannina in Northwestern Greece. The comorbidity with other autoimmune diseases was investigated in this population by autoantibody evaluation.
RESULTS
Of the 49 children with CSU, 1 had autoantibodies for celiac disease (CD), which was confirmed by duodenal biopsy via gastroscopy. Four children had high serum levels of anti-thyroid peroxidase antibodies but normal thyroid function. No other specific autoantibodies were detected.
CONCLUSION
The prevalence of autoimmune diseases among our children with CSU was low. Nevertheless, we think it is important to test children with CSU for other autoimmune diseases. CD can be diagnosed in children with CSU even in the absence of other indicative signs.
简介
儿童慢性自发性荨麻疹（CSU）会影响患者的生活质量，并且可能与其他自身免疫性疾病相关。本研究旨在探讨儿童 CSU 与自身免疫性疾病的关联。
方法
在 2015 年至 2018 年的 3 年期间，49 名儿童被诊断为 CSU，并在希腊西北部约阿尼纳大学医院的儿科过敏门诊进行监测。通过自身抗体评估，在该人群中调查了其他自身免疫性疾病的合并症。
结果
在 49 名患有 CSU 的儿童中，1 名儿童的抗麸质抗体（CD）阳性，通过胃镜下十二指肠活检得到了证实。4 名儿童的血清抗甲状腺过氧化物酶抗体水平较高，但甲状腺功能正常。未检测到其他特定的自身抗体。
结论
我们的 CSU 患儿中自身免疫性疾病的患病率较低。尽管如此，我们认为对 CSU 患儿进行其他自身免疫性疾病的检测是很重要的。即使没有其他指示性迹象，也可以在患有 CSU 的儿童中诊断 CD。
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