经口 CO2 激光声带切除术治疗早期声门型喉癌的肿瘤学和功能学结果。
Oncologic and functional outcomes of transoral CO2 laser cordectomy for early glottic cancer.
机构信息
Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan; Department of Otorhinolaryngology, University of the Philippines Manila & Philippine General Hospital, Manila, Philippines.
Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
出版信息
Auris Nasus Larynx. 2020 Apr;47(2):276-281. doi: 10.1016/j.anl.2019.08.005. Epub 2019 Sep 13.
OBJECTIVE
To investigate the oncological and functional outcomes of the patients treated with transoral CO2 laser cordectomy for early glottic cancer.
PATIENTS AND METHODS
Fifty-five consecutive patients who underwent CO2 laser cordectomy for early glottic cancer were retrospectively reviewed.
RESULTS
Overall survival, larynx preservation, and relapse free local control rates were 96%, 100%, and 91%, respectively. Five patients with local recurrences were salvaged with re-cordectomy and/or radiotherapy. In type I cordectomy, VHI-10 consistently improved during postoperative course and VHI-10 at postoperative 12months was significantly better than preoperative value (2.3 vs. 9.4, p=0.02). Perceptual grading, MPT, MFR and AC/DC also improved and were better than preoperative values. In type III cordectomy, shimmer at 12months after cordectomy was significantly better than preoperative value (14.7 vs. 9.3, p=0.007).
CONCLUSIONS
These results further support the rationale of CO2 cordectomy as initial and salvage surgery for early glottic cancer.
目的
探讨经口 CO2 激光声带切除术治疗早期声门型喉癌的肿瘤学和功能结局。
方法
回顾性分析了 55 例因早期声门型喉癌接受 CO2 激光声带切除术的连续患者。
结果
总生存率、喉保留率和无局部复发生存率分别为 96%、100%和 91%。5 例局部复发患者通过再声带切除术和/或放疗得以挽救。在 I 型声带切除术患者中，VHI-10 在术后过程中持续改善，术后 12 个月的 VHI-10 明显优于术前值（2.3 比 9.4，p=0.02）。感知评分、MPT、MFR 和 AC/DC 也有所改善，优于术前值。在 III 型声带切除术患者中，术后 12 个月的声扰值明显优于术前值（14.7 比 9.3，p=0.007）。
结论
这些结果进一步支持了 CO2 声带切除术作为早期声门型喉癌初始和挽救性手术的原理。
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