分析自闭症谱系障碍患者的肠道微生物组、营养和免疫状况：厄瓜多尔的病例对照研究。
Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador.
机构信息
Facultad de Ciencias de la Salud, Universidad Técnica de Ambato , Ambato, Ecuador.
Centro de Investigación Traslacional, Universidad de las Américas , Quito, Ecuador.
出版信息
Gut Microbes. 2020 May 3;11(3):453-464. doi: 10.1080/19490976.2019.1662260. Epub 2019 Sep 18.
Abstract
Most studies on autism spectrum disorder (ASD) risk factors have been conducted in developed countries where ethnicity and environment are different than in developing countries. We compared nutritional status, immune response and microbiota composition in mestizo children with ASD with matched controls in Ecuador. Twenty-five cases and 35 controls were matched by age, sex and school location. The prevalence of under- and overweight was higher in children with ASD. Nutritional differences were accompanied by abnormal food habits and more frequent gastrointestinal symptoms in children with ASD. Also, greater serum concentrations of TGF-β1 were observed in children with ASD. Finally, there was greater alpha diversity and abundance of (2 OTUs), and different species of in ASD children.
摘要
大多数自闭症谱系障碍 (ASD) 风险因素的研究都是在发达国家进行的，这些国家的种族和环境与发展中国家不同。我们比较了厄瓜多尔的 ASD 患儿和匹配对照儿的营养状况、免疫反应和微生物群落组成。25 例病例和 35 例对照按年龄、性别和学校地点匹配。ASD 患儿的消瘦和超重发生率较高。营养差异伴随着 ASD 患儿异常的饮食习惯和更频繁的胃肠道症状。此外，ASD 患儿的血清 TGF-β1 浓度也更高。最后，ASD 患儿的 α多样性和丰度更高，以及不同种类的 。
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