A Mozaffari, M Ghorbani
Medical Physics Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Biomed Phys Eng. 2019 Aug 1;9(4):425-436. doi: 10.31661/jbpe.v0i0.570. eCollection 2019 Aug.
Brachytherapy sources are widely used for the treatment of cancer. The report of Task Group No. 43 (TG-43) of American Association of Physicists in Medicine is known as the most common method for the determination of dosimetric parameters for brachytherapy sources. The aim of this study is to obtain TG-43 dosimetric parameters for Co, Cs, Ir and Pd brachytherapy sources by Monte Carlo simulation.
In this study, Co (model Co0.A86), Cs (model 6520-67), Ir (model BEBIG) and Pd (model OptiSeed) brachytherapy sources were simulated using MCNPX Monte Carlo code. To simulate the sources, the exact geometric characterization of each source was defined in Monte Carlo input programs. Dosimetric parameters including air kerma strength, dose rate constant, radial dose function and anisotropy function were calculated for each source. Each input program was run with sufficient number of particle histories. The maximum type A statistical uncertainty in the simulation of the Co, Cs, Ir and Pd sources, were equal to 4%, 4%, 3.19% and 6.50%, respectively.
The results for dosimetry parameters of dose rate constant, radial dose function and anisotropy function for the Co, Cs, Ir and Pd sources in this study demonstrated good agreement with other studies.
Based on the good agreement between the results of this study and other studies, the TG-43 results for Co0.A86 Co, 67-65200 Cs, BEBIG Ir and OptiSeed Pd sources are validated and can be used as input data in treatment planning systems (TPSs) and to validate the TPS calculations.
近距离放射治疗源广泛应用于癌症治疗。美国医学物理学家协会第43任务组(TG - 43)的报告是确定近距离放射治疗源剂量学参数最常用的方法。本研究的目的是通过蒙特卡罗模拟获得钴、铯、铱和钯近距离放射治疗源的TG - 43剂量学参数。
在本研究中,使用MCNPX蒙特卡罗代码模拟了钴(型号Co0.A86)、铯(型号6520 - 67)、铱(型号BEBIG)和钯(型号OptiSeed)近距离放射治疗源。为了模拟这些源,在蒙特卡罗输入程序中定义了每个源的确切几何特征。计算了每个源的剂量学参数,包括空气比释动能强度、剂量率常数、径向剂量函数和各向异性函数。每个输入程序都运行了足够数量的粒子历史。钴、铯、铱和钯源模拟中的最大A类统计不确定度分别等于4%、4%、3.19%和6.50%。
本研究中钴、铯、铱和钯源的剂量率常数、径向剂量函数和各向异性函数的剂量学参数结果与其他研究结果显示出良好的一致性。
基于本研究结果与其他研究结果的良好一致性,Co0.A86钴、67 - 65200铯、BEBIG铱和OptiSeed钯源的TG - 43结果得到验证,可作为治疗计划系统(TPS)的输入数据并用于验证TPS计算。